212628-45-0

Basic information

• Product Name: Benzoic acid, 3,4-difluoro-2-[(4-iodo-2-methylphenyl)amino]-
• CAS NO: 212628-45-0
• Molecular Formula: C14H10F2INO2
• Molecular Weight: 389.14
• Mol File: 212628-45-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3,4-difluoro-2-[(4-iodo-2-methylphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3,4-difluoro-2-[(4-iodo-2-methylphenyl)amino]-(212628-45-0)
• EPA Substance Registry System: Benzoic acid, 3,4-difluoro-2-[(4-iodo-2-methylphenyl)amino]-(212628-45-0)

Safety Data

• Hazardous Substances Data: 212628-45-0(Hazardous Substances Data)

Upstream product

• 13194-68-8 4-iodo-2-methylaniline 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 284032-13-9 [6-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-2,3-difluoro-phenyl]-(4-iodo-2-methyl-phenyl)-amine 
• 284033-41-6 3,4-Difluoro-2-(4-iodo-2-methyl-phenylamino)-benzoic acid hydrazide 
• 1100178-07-1 3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-(Z)-2-butenoxy-benzamide 
• 212630-57-4 3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-isopropoxy-benzamide 
• 1100178-06-0 3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-isopropenoxy-benzamide 
• 212630-53-0 3,4-difluoro-2-(4-iodo-2-methyl-phenylamino)-N-methoxy-benzamide 

Relevant articles and documents

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles-O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

This paper reports a second generation MEK inhibitor. The previously reported potent and efficacious MEK inhibitor, PD-184352 (CI-1040), contains an integral hydroxamate moiety. This compound suffered from less than ideal solubility and metabolic stabilit

Treatment of asthma with MEK inhibitors

This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II:

A simple and efficient synthesis of 2-(N-phenylamino)-benzoic acids

A new method for the synthesis of 2-(N-phenylamino)benzoic acids is presented, with 2-fluorobenzoic acids and anilines as starting materials. Several experimental conditions as well as the factors influencing the outcome of the reaction are described.