212779-21-0

Basic information

• Product Name: 2-Amino-3-bromo-6-chloropyrazine
• Synonyms: 2-Amino-3-bromo-6-chloropyrazine;2-PyrazinaMine, 3-broMo-6-chloro-;3-Bromo-6-chloro-2-pyrazinamine;3-Bromo-6-chloro-pyrazin-2-ylamine
• CAS NO: 212779-21-0
• Molecular Formula: C4H3BrClN3
• Molecular Weight: 208.446
• Mol File: 212779-21-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.960
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.05±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-bromo-6-chloropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)
• EPA Substance Registry System: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)

Safety Data

• Hazardous Substances Data: 212779-21-0(Hazardous Substances Data)

Usage

General Description

2-Amino-3-bromo-6-chloropyrazine is a chemical compound that is categorized under the class of pyrazines, organic compounds characterized by a pyrazine ring—a six-membered aromatic ring with two nitrogen atoms. Apart from its chemical formula, specific details about the physical and chemical properties of this compound such as boiling point, density, molecular weight, and solubility, among others, may not be readily and extensively available. Its specific use or purpose and possible implications in various industries (e.g. pharmaceutical, chemical manufacturing, etc.) might also need more specialized and targeted research or references. As with other chemicals, appropriate safety measures should be considered when handling 2-Amino-3-bromo-6-chloropyrazine to prevent potential health risks or hazards.

InChI:InChI=1/C4H3BrClN3/c5-3-4(7)9-2(6)1-8-3/h1H,(H2,7,9)

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 33332-28-4 2-amino-6-chloropyrazine 

Downstream Products

• 1801693-41-3 tert-butyl N-(3-bromo-6-chloropyrazin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate 

Relevant articles and documents

Synthesis process of 2-amino-3-bromo-6-chloropyrazine

The invention relates to a synthesis process of 2-amino-3-bromo-6-chloropyrazine, which comprises the following steps: 1) adding 2-amino-6-chloropyrazine into an organic solvent, cooling the system, and then adding a catalyst; (2) dropwise adding a bromination reagent, namely liquid bromine, into the system, after dropwise adding is finished, carrying out heat preservation reaction, and carrying out TLC detection and tracking reaction; and 3) adding a sodium sulfite solution into the system until reddish brown fades, extracting with chloroform, washing with water, drying with anhydrous sodium sulfate, concentrating, passing through a silicagel column roughly, and recrystallizing to obtain the yellow solid compound 2-amino-3-bromine- 6-chloropyrazine. 2-amino-3-bromine- 6-chloropyrazine is used as an initial raw material and is brominated to obtain the product, so that the method is simple to operate, short in step, easily available in raw material, simple to purify, high in yield, low in cost and easy for large-scale production.

PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II wit

COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.