21286-60-2Relevant articles and documents
Migratory hydroamination: A facile enantioselective synthesis of benzomorphans
Trost, Barry M.,Tang, Weiping
, p. 8744 - 8745 (2007/10/03)
We describe a highly efficient, general strategy for the enantioselective synthesis of benzomorphans (45-46% overall yield from commercially available material). The new synthesis demonstrates the effectiveness of an unprecedented diastereoselective cycloisomerization via migratory hydroamination and the power of palladium-catalyzed asymmetric allylic alkylation (AAA) of simple ketone enolates in the context of complex synthesis. The strategy outlined here for the enantioselective synthesis of three contiguous stereogenic centers and the novel cycloisomerization should have many applications in alkaloid synthesis. Copyright
An improved resolution of (±)-cis-N-normetazocine
Brine,Berrang,Hayes,Carroll
, p. 2139 - 2143 (2007/10/02)
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