212914-74-4 Usage
Description
2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI) is an organic compound that features a pyridine ring with a formyl group at the 2nd position and a hydroxymethyl group at the 4th position. This unique structure endows it with potential applications in various fields, particularly in pharmaceutical chemistry.
Uses
Used in Pharmaceutical Industry:
2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI) is used as a reactant for the preparation of edotecarin analogues, which are potent topoisomerase I inhibitors. These analogues exhibit significant cytotoxic activities against various cancer cell lines, such as MKN-45 human stomach cancer and MX-1 human breast cancer. 2-Pyridinecarboxaldehyde,4-(hydroxymethyl)-(9CI)'s ability to inhibit topoisomerase I, an essential enzyme in DNA replication, makes it a valuable component in the development of anticancer drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 212914-74-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,2,9,1 and 4 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 212914-74:
(8*2)+(7*1)+(6*2)+(5*9)+(4*1)+(3*4)+(2*7)+(1*4)=114
114 % 10 = 4
So 212914-74-4 is a valid CAS Registry Number.
212914-74-4Relevant articles and documents
Selective DIBAL-H Monoreduction of a Diester Using Continuous Flow Chemistry: From Benchtop to Kilo Lab
Uhlig, Nick,Martins, Andrew,Gao, Detian
, p. 2326 - 2335 (2020/06/08)
Herein we report a selective DIBAL-H-mediated reduction of a heterocyclic diester to the corresponding monoaldehyde using continuous flow chemistry. The use of continuous flow enabled operation at lower temperatures and better control of the reaction time, thereby allowing for a significant increase in reaction selectivity and yield compared with batch conditions. The reaction's development as a continuous flow process and its scale-up from laboratory gram scale to multikilogram scale are discussed, including design of experiments studies to probe the optimal reaction window.
