21303-01-5Relevant articles and documents
Synthesis of mexiletine analogues from non-activated aziridines
Ingebrigtsen, Truls,Lejon, Tore
, p. 891 - 902 (2008/03/13)
A general method for the synthesis of mexiletine analogues by nucleophilic ring opening of non-activated racemic aziridines has been developed (Scheme 1). Structural variation is introduced by employing different nucleophiles or by altering the substitution on the aziridine ring.