21320-30-9

Basic information

• Product Name: 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE
• Synonyms: 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE;3-(3,4-Dichlorophenoxy)-1,2-propenoxide, 3-(3,4-Dichlorophenoxy)-1,2-epoxypropane
• CAS NO: 21320-30-9
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.06462
• Mol File: 21320-30-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 310.7°C at 760 mmHg
• Flash Point: 127.1°C
• Appearance: /
• Density: 1.389g/cm³
• Vapor Pressure: 0.00108mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE(21320-30-9)
• EPA Substance Registry System: 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE(21320-30-9)

Safety Data

• Hazardous Substances Data: 21320-30-9(Hazardous Substances Data)

Usage

General Description

The chemical 2-[(3,4-DICHLOROPHENOXY)METHYL]OXIRANE, also known as epichlorohydrin, is a reactive, colorless liquid compound with a pungent odor. It is widely used in the production of epoxy resins, which are used in a variety of applications including adhesives, coatings, and plastics. Epichlorohydrin is also used in the manufacture of glycerol, pharmaceuticals, and as a solvent for resins and waxes. However, it is considered a hazardous substance, as it is toxic and can be harmful if inhaled, ingested, or in contact with the skin. It is also a potential carcinogen and can cause irritation to the respiratory system and skin. Therefore, it must be handled with care and proper protective measures.

InChI:InChI=1/C9H8Cl2O2/c10-8-2-1-6(3-9(8)11)12-4-7-5-13-7/h1-3,7H,4-5H2

Upstream product

• 39975-26-3 sodium 3,4-dichlorophenoxide 
• 106-89-8 epichlorohydrin 
• 95-77-2 3,4-dichlorophenol 

Downstream Products

• 132948-72-2 1-(3,4-Dichloro-phenoxy)-3-piperidin-1-yl-propan-2-ol 
• 5790-30-7 3-<3.4-Dichlor-phenoxy>-1-isopropylamino-propanol-(2) 
• 59692-59-0 1-(3,4-dichlorophenoxy)-3-tert-butylamino-2-propanol 
• 1311146-80-1 1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(3,4-dichlorophenoxy)propan-2-ol 

Relevant articles and documents

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Development of β-amino alcohol derivatives that inhibit toll-like receptor 4 mediated inflammatory response as potential antiseptics

Toll-like receptor 4 (TLR4) induced proinflammatory signaling has been directly implicated in severe sepsis and represents an attractive therapeutic target. Herein, we report our investigations into the structure-activity relationship and preliminary drug metabolism/pharmacokinetics study of β-amino alcohol derivatives that inhibit the TLR4 signaling pathway. Lead compounds were identified from in vitro cellular examination with micromolar potency for their inhibitory effects on TLR4 signaling and subsequently assessed for their ability to suppress the TLR4-induced inflammatory response in an ex vivo whole blood model. In addition, the toxicology, specificity, solubility, brain-blood barrier permeability, and drug metabolism of several compounds were evaluated. Although further optimizations are needed, our findings lay the groundwork for the future drug development of this class of small molecule agents for the treatment of severe sepsis.

1-Aryloxy-3-substituted aminopropan-2-ols, aminomethyl substituted phenols and 1,3-benzoxazines as potential spermicides

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