21320-37-6

Basic information

• Product Name: 6-(CHLOROMETHYL)-N,N-DIMETHYL-1,3,5-TRIAZINE-2,4-DIAMINE
• Synonyms: [4-amino-6-(chloromethyl)-s-triazin-2-yl]-dimethyl-amine
• CAS NO: 21320-37-6
• Molecular Formula: C6H10ClN5
• Molecular Weight: 187.63
• Mol File: 21320-37-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 385.8°C at 760 mmHg
• Flash Point: 187.1°C
• Appearance: /
• Density: 1.368g/cm³
• Vapor Pressure: 3.7E-06mmHg at 25°C
• Refractive Index: 1.631
• CAS DataBase Reference: 6-(CHLOROMETHYL)-N,N-DIMETHYL-1,3,5-TRIAZINE-2,4-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(CHLOROMETHYL)-N,N-DIMETHYL-1,3,5-TRIAZINE-2,4-DIAMINE(21320-37-6)
• EPA Substance Registry System: 6-(CHLOROMETHYL)-N,N-DIMETHYL-1,3,5-TRIAZINE-2,4-DIAMINE(21320-37-6)

Safety Data

• Hazardous Substances Data: 21320-37-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H10ClN5/c1-12(2)6-10-4(3-7)9-5(8)11-6/h3H2,1-2H3,(H2,8,9,10,11)

Upstream product

• 1115-70-4 metformin hydrochloride 
• 96-34-4 methyl chloroacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1443221-44-0 N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide 
• 1443221-58-6 N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)furan-2-carboxamide 
• 1443221-46-2 N-[5-(4-amino-6-dimethylamino-[1,3,5]triazin-2-yl)-4-phenylthiazol-2-yl]benzamide 

Relevant articles and documents

New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides

A series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamide and furamide analogues were investigated in radioligand binding studies at adenosine receptor subtypes with an aim to obtain potent and selective adenosine receptor ligands. Benzamide and furamide linked to thiazole was found to be crucial for high adenosine receptor affinity. The most potent compound indentified in this study was 5d with low nanomolar affinity for all four adenosine receptor subtypes. Compounds 5a and 5g showed moderate selectivity for A2A adenosine receptors. Molecular docking versus all four human adenosine receptors combined with membrane molecular dynamics studies were performed to rationalise the peculiar selectivity profile of 5d antagonist.

Synthetic antibacterials. I. Nitrofurylvinyl-s-triazine derivatives.

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