213257-69-3

Basic information

• Product Name: Methanone, diphenyl-, (2-methylphenyl)hydrazone
• CAS NO: 213257-69-3
• Molecular Formula: C20H18N2
• Molecular Weight: 286.376
• Mol File: 213257-69-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, diphenyl-, (2-methylphenyl)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, diphenyl-, (2-methylphenyl)hydrazone(213257-69-3)
• EPA Substance Registry System: Methanone, diphenyl-, (2-methylphenyl)hydrazone(213257-69-3)

Safety Data

• Hazardous Substances Data: 213257-69-3(Hazardous Substances Data)

Upstream product

• 615-37-2 ortho-methylphenyl iodide 
• 5350-57-2 benzophenone hydrazone 
• 41480-08-4 2-methylphenyl benzenesulfonate 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 119-61-9 benzophenone 
• 1236203-12-5 3-phenyl-1-(o-tolyl)-1H-indazole 
• 91565-80-9 3,5-dimethyl-1-(o-tolyl)-1H-pyrazole 
• 337533-96-7 5-tert-butyl-2-o-tolyl-2H-pyrazol-3-yl-amine 

Relevant articles and documents

Nickel-catalyzed N-arylation of benzophenone hydrazone with bromoarenes

A nickel-catalyzed method for the cross-coupling of benzophenone hydrazone with aryl bromides is described. The use of a simple Ni(ii)/NHC catalyst leads to the arylated hydrazones in good or acceptable yields. This protocol provides a simple, convenient alternative to the synthesis of arylhydrazines.

Industrial-scale palladium-catalyzed coupling of aryl halides and amines - A personal account

The palladium-catalyzed coupling of amines and aryl halides or aryl alcohol derivatives has matured from an exotic small-scale transformation into a very general, efficient and robust reaction during the last ten years. This article reports several applications of this method from an industrial vantage point, including ligand synthesis, synthesis of arylpiperazines, arylhydrazines and diarylamines. Much emphasis in placed on issues of scale-up and safety to underline the potential of C-N couplings as solutions for industrial-scale synthetic problems.

Tandem hydroformylation/Fischer indole synthesis: A novel and convenient approach to indoles from olefins

(Matrix presented) A novel one-pot synthesis of indole systems via tandem hydroformylation/Fischer indole synthesis starting from olefins and arylhydrazines is described. This tandem procedure leads directly to 3-substituted indoles if unsubstituted phenylhydrazine is used and to 3,5- respectively 3,7-disubstituted indoles if para- or ortho-substituted arylhydrazines are used.