213270-36-1

Basic information

• Product Name: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER
• Synonyms: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER , EE98%;(S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER, 98+%, EE 98+;(S)-2-ISOBUTYLSUCCINIC ACID-1-METHYL ESTER, 95%, (98% EE);(S)-2-Isobutylsuccinic acid-1-Methyl ester, (98% ee);(S)-3-METHOXYCARBONYL-5-METHYLHEXANOIC ACID;(S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER;(S)-2-ISOBUTYLSUCCINIC ACID-1-METHYL ESTER
• CAS NO: 213270-36-1
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.22
• EINECS: -0
• Mol File: 213270-36-1.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 243.23°C (rough estimate)
• Flash Point: 108°C
• Appearance: /
• Density: 1.0725 (rough estimate)
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.4240 (estimate)
• Storage Temp.: Refrigerator (+4°C)
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 8110824
• CAS DataBase Reference: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(213270-36-1)
• EPA Substance Registry System: (S)-(-)-2-ISOBUTYLSUCCINIC ACID 1-METHYL ESTER(213270-36-1)

Safety Data

• Safety Statements: 24/25
• RIDADR: UN2810
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 213270-36-1(Hazardous Substances Data)

Usage

Description

(S)-(-)-2-Isobutylsuccinic acid 1-methyl ester is a clear yellow viscous liquid that serves as a crucial pharmaceutical intermediate. It is an organic compound with the molecular formula C9H16O4 and is known for its significant role in the synthesis of various pharmaceuticals.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-2-Isobutylsuccinic acid 1-methyl ester is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical properties make it a valuable component in the development of new medications, contributing to the advancement of healthcare and pharmaceutical research.
As a key intermediate, (S)-(-)-2-Isobutylsuccinic acid 1-methyl ester plays a vital role in the production of different pharmaceutical compounds, which can be used to treat a wide range of medical conditions. Its versatility in chemical reactions and stability as a compound make it an essential building block in the pharmaceutical industry.

InChI:InChI=1/C9H16O4/c1-6(2)4-7(5-8(10)11)9(12)13-3/h6-7H,4-5H2,1-3H3,(H,10,11)

Upstream product

• 78-84-2 isobutyraldehyde 
• 106-65-0 Dimethyl succinate 
• 130165-75-2 (E)-2-(1-isobutylidene)succinic acid 1-methyl ester 

Downstream Products

• 927828-11-3 (S)-methyl 4-methyl-2-(2-((S)-1-(methylamino)-1-oxo-4-phenylbutan-2-ylamino)-2-oxoethyl)pentanoate 

Relevant articles and documents

A Bulky Three-Hindered Quadrant Bisphosphine Ligand: Synthesis and Application in Rhodium-Catalyzed Asymmetric Hydrogenation of Functionalized Alkenes

A bulky three-hindered quadrant bisphosphine ligand, di-1-adamantylphosphino(tert-butylmethylphosphino)methane, named BulkyP*, has been synthesized via a convergent short pathway with chromatography-free procedures. The ligand is a crystalline solid and can be readily handled in air. Its rhodium(I) complex exhibits very high enantioselectivities and catalytic activities in the asymmetric hydrogenation of functionalized alkenes.

Highly enantioselective hydrogenation of itaconic acid derivatives with a chiral bisphospholane-Rh(I) catalyst

The new - commercially in multi-kg quantities available - chiral bisphospholane ligand, catA-Sium M, has been successfully used in the Rh(I)-catalysed enantioselective hydrogenation of itaconic acid derivatives. Chiral β-substituted succinic acid derivati

A Novel Chiral Ferrocenyl Phosphine Ligand from Sugar: Applications in Rh-Catalyzed Asymmetric Hydrogenation Reactions

(Matrix Presented) A new chiral ferrocenyl diphosphine ligand 3 was synthesized from readily available D-mannitol. Rh-complex with this ligand showed high enantioselectivity and reactivity in the asymmetric hydrogenation of dehydroamino acid derivatives and itaconic acid derivatives. Up to over 99% ee and 10 000 TON were achieved with this catalytic system.