21331-58-8Relevant articles and documents
Strausz et al.
, p. 1930 (1968)
A concise total synthesis of (?)-γ-lycorane via an aromatic C[sbnd]H alkylation of unactivated secondary alkyl iodide
Huang, Shuangping,Ou, Wentao,Pang, Yiying,Wang, Xiaoji,Xiao, Hesheng,Zhang, Xuesong
supporting information, (2020/03/04)
A concise and straightforward total synthetic approach towards lycorine-type alkaloid (?)-γ-lycorane has been achieved in 7 steps. The key feature of the route is the employment of a palladium-catalyzed aromatic C[sbnd]H alkylation of unactivated secondary alkyl iodide. The synthetic protocols also involve a palladium-catalyzed deracemization of allylic carbonate, a Johnson-Claisen rearrangement and an iodocyclization.
Method for synthesizing natural product gamma-lycorane
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Paragraph 0026; 0027, (2019/02/27)
The invention discloses a method for synthesizing a natural product gamma-lycorane. A classical Johnson-claisen rearrangement reaction, an I2 catalyzed N heterocyclic construction reaction, a palladium-catalyzed coupled ring closing reaction and the like
Rapid Access to Thiolactone Derivatives through Radical-Mediated Acyl Thiol-Ene and Acyl Thiol-Yne Cyclization
McCourt, Ruairi O.,Dénès, Fabrice,Sanchez-Sanz, Goar,Scanlan, Eoin M.
supporting information, p. 2948 - 2951 (2018/05/28)
A new synthetic approach to thiolactones that employs an efficient acyl thiol-ene (ATE) or acyl thiol-yne (ATY) cyclization to convert unsaturated thiocarboxylic acid derivatives into thiolactones under very mild conditions is described. The high overall yields, fast kinetics, high diastereoselectivity, excellent regiocontrol, and broad substrate scope of these reaction processes render this a very useful approach for diversity-oriented synthesis and drug discovery efforts. A detailed computational rationale is provided for the observed regiocontrol.