213390-51-3Relevant articles and documents
Thiaisatoic anhydrides: Efficient synthesis under microwave heating conditions and study of their reactivity
Fabis, Frederic,Jolivet-Fouchet, Sandrine,Robba, Max,Landelle, Henriette,Rault, Sylvain
, p. 10789 - 10800 (2007/10/03)
2-thiaisatoic anhydride 1 and 3-thiaisatoic anhydride 2 were synthesized in large scale under microwave heating conditions with 85% and 67% yields respectively. The reactivity of these two compounds was studied towards various nucleophiles and appeared to be generally different from that of isatoic anhydride: many new thiophene-2 and 3-carboxylic acids were isolated with good yields as potential new pharmacological scaffolds.