21344-73-0

Basic information

• Product Name: ALLYL-(4-PHENYL-THIAZOL-2-YL)-AMINE
• Synonyms: 2-thiazolamine, 4-phenyl-N-2-propen-1-yl-; N-Allyl-4-phenyl-1,3-thiazol-2-amine
• CAS NO: 21344-73-0
• Molecular Formula: C₁₂H₁₂N₂S
• Molecular Weight: 216.3
• Mol File: 21344-73-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 73 °C(Solv: ethanol (64-17-5))
• Boiling Point: 357.5°C at 760 mmHg
• Flash Point: 170°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 2.71E-05mmHg at 25°C
• Refractive Index: 1.631
• PKA: 3.86±0.10(Predicted)
• CAS DataBase Reference: ALLYL-(4-PHENYL-THIAZOL-2-YL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: ALLYL-(4-PHENYL-THIAZOL-2-YL)-AMINE(21344-73-0)
• EPA Substance Registry System: ALLYL-(4-PHENYL-THIAZOL-2-YL)-AMINE(21344-73-0)

Safety Data

• Hazardous Substances Data: 21344-73-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H12N2S/c1-2-8-13-12-14-11(9-15-12)10-6-4-3-5-7-10/h2-7,9H,1,8H2,(H,13,14)

Upstream product

• 109-57-9 Allylthiourea 
• 70-11-1 α-bromoacetophenone 
• 98-86-2 acetophenone 
• 333-20-0 potassium thioacyanate 
• 100-42-5 styrene 

Relevant articles and documents

One-pot synthesis of 4-aryl-2-aminothiazoles from styrenes and thioureas promoted by tribromoisocyanuric acid

A simple and efficient one-pot protocol has been developed for the conversion of styrenes into 4-aryl-2-aminothiazoles using readily available starting materials. Tribromoisocyanuric acid was successfully used for the co-bromination and oxidation of styrenes to give phenacyl bromides, which in the presence of thioureas produced the corresponding 4-aryl-2-aminothiazoles in 48–70% yield. The protocol involves three reactions in one process: a tandem (formation of phenacyl bromides from styrenes) followed by a telescoped (conversion to thiazole) reaction.

One pot synthesis using supported reagents system KSCN/SiO 2-RNH3OAc/Al2O3: Synthesis of 2-aminothiazoles and N-allylthioureas

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH 3OAc/Al2O3, in which α-halo ketone reacts first KSCN/SiO2 and the product, α-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO 2 and the product, allyl isothiocyanate, reacts with RNH 3OAc/Al2O3 to give N-allylthiourea.