213481-12-0

Basic information

• Product Name: 3-(Benzo[d][1,3]dioxol-5-yl)-4-phenylfuran-2,5-dione
• Synonyms: CHEMBL603434;213481-12-0;SCHEMBL4751583;3-(benzo[d][1,3]dioxol-5-yl)-4-phenylfuran-2,5-dione;BPD, >=98% (HPLC);BDBM50305802;L018191
• CAS NO: 213481-12-0
• Molecular Weight: 294.263
• Mol File: 213481-12-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(Benzo[d][1,3]dioxol-5-yl)-4-phenylfuran-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Benzo[d][1,3]dioxol-5-yl)-4-phenylfuran-2,5-dione(213481-12-0)
• EPA Substance Registry System: 3-(Benzo[d][1,3]dioxol-5-yl)-4-phenylfuran-2,5-dione(213481-12-0)

Safety Data

• Hazardous Substances Data: 213481-12-0(Hazardous Substances Data)

Upstream product

• 2861-28-1 1,3-benzodioxole-5-acetic acid 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 1082068-50-5 3-benzo[1,3]dioxol-5-yl-4-phenyl-1H-pyrrol-2,5-dione 
• 1026674-65-6 3-(3,4-dihydroxyphenyl)-4-phenyl-1H-pyrrol-2,5-dione 

Relevant articles and documents

Synthesis and PGE2 production inhibition of 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives

3,4-Diphenyl-substituted 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione derivatives were synthesized and evaluated for the inhibitory activities on LPS-induced PGE2 production in RAW 264.7 macrophage cells. Both 1H-furan-2,5-dione and 1H-pyrrole-2,5-dione rings as main scaffolds were easily obtained using one of three synthetic methods. Among the compounds investigated, 1H-3-(4-sulfamoylphenyl)-4-phenyl-pyrrole-2,5-dione (6l) showed a strong inhibitory activity (IC50 = 0.61 μM) of PGE2 production.