2137030-98-7 Usage
Description
Ensartinib hydrochloride, also known as X-396, is the salt form of Ensartinib, an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. It is characterized by its ability to bind and inhibit ALK kinase, ALK fusion proteins, and ALK point mutation variants, thereby disrupting ALK-mediated signaling and inhibiting tumor cell growth in ALK-expressing tumor cells. ALK, a member of the insulin receptor superfamily, plays a crucial role in nervous system development.
Uses
Used in Anticancer Applications:
Ensartinib hydrochloride is used as an antineoplastic agent for the treatment of various cancers, particularly those expressing the anaplastic lymphoma kinase (ALK). It works by inhibiting ALK kinase, ALK fusion proteins, and ALK point mutation variants, which leads to the disruption of ALK-mediated signaling and the inhibition of tumor cell growth in ALK-expressing tumor cells.
Used in Pharmaceutical Industry:
Ensartinib hydrochloride is used as a key component in the development of targeted cancer therapies. Its ability to inhibit ALK kinase and related proteins makes it a valuable asset in the creation of drugs that specifically target cancer cells, potentially reducing side effects and improving treatment outcomes for patients with ALK-positive tumors.
Used in Research and Development:
Ensartinib hydrochloride is used as a research tool for studying the role of ALK in cancer cell growth and the development of novel therapeutic strategies. Its specificity for ALK makes it a valuable compound for investigating the molecular mechanisms underlying ALK-mediated signaling pathways and the potential for developing new drugs that target these pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 2137030-98-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,1,3,7,0,3 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2137030-98:
(9*2)+(8*1)+(7*3)+(6*7)+(5*0)+(4*3)+(3*0)+(2*9)+(1*8)=127
127 % 10 = 7
So 2137030-98-7 is a valid CAS Registry Number.
2137030-98-7Relevant articles and documents
SOLID STATE FORMS OF ENSARTINIB AND ENSARTINIB SALTS
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Paragraph 00133, (2022/02/15)
The present disclosure encompasses solid state forms and co-crystals of Ensartinib and of Ensartinib salts, in embodiments crystalline polymorphs of Ensartinib and of Ensartinib salts and co-crystals, processes for preparation thereof, and pharmaceutical compositions thereof.
