213743-31-8 Usage
Description
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR is a cell-permeable pyrrolopyrimidine compound that acts as a potent, reversible, selective, and ATP-competitive inhibitor of Lck (Lyn protein-tyrosine kinase). It is characterized by its ability to inhibit Lck with high potency and selectivity, while minimally affecting the activities of other kinases.
Uses
Used in Pharmaceutical Industry:
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR is used as an Lck Inhibitor for its ability to inhibit Lck, a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Its high potency and selectivity make it a valuable tool in the development of targeted therapies for conditions involving the dysregulation of Lck activity.
Additionally, 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR has been shown to potently block T-cell receptor-stimulated IL-2 production in vitro and in vivo, suggesting its potential use in immunological applications, particularly in the treatment of autoimmune diseases and transplantation.
In Research Applications:
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR is used as a research tool for studying the role of Lck in various cellular processes and signaling pathways. Its high potency and selectivity make it an ideal compound for investigating the molecular mechanisms underlying Lck-mediated cellular responses and for identifying potential therapeutic targets in various diseases.
In Drug Discovery and Development:
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR is used as a lead compound in the development of novel inhibitors targeting Lck and related kinases. Its unique structure and properties provide a foundation for the design and synthesis of new compounds with improved potency, selectivity, and pharmacological properties, ultimately leading to the development of more effective therapeutic agents for various diseases.
Biochem/physiol Actions
Primary TargetLck?????? Y3
Check Digit Verification of cas no
The CAS Registry Mumber 213743-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,7,4 and 3 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 213743-31:
(8*2)+(7*1)+(6*3)+(5*7)+(4*4)+(3*3)+(2*3)+(1*1)=108
108 % 10 = 8
So 213743-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H22N4O/c24-22-21-20(14-27(17-6-4-5-7-17)23(21)26-15-25-22)16-10-12-19(13-11-16)28-18-8-2-1-3-9-18/h1-3,8-15,17H,4-7H2,(H2,24,25,26)
213743-31-8Relevant articles and documents
A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors
Devine, Shane M.,Lim, San Sui,Chandrashekaran, Indu R.,Macraild, Christopher A.,Drew, Damien R.,Debono, Cael O.,Lam, Raymond,Anders, Robin F.,Beeson, James G.,Scanlon, Martin J.,Scammells, Peter J.,Norton, Raymond S.
supporting information, p. 1500 - 1506 (2014/12/10)
We have determined that a previously reported class of pyrrolo[2,3-d]pyrimidine-4-amines exhibit low binding to apical membrane antigen 1 (AMA1) and suffer from unattractive qualities, such as aggregation. We attempted to remove these traits by generating
PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS
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, (2008/06/13)
Compounds of formula I including pharmaceutically acceptable salts thereof in which R1 represents hydrogen, 2-phenyl-1,3-dioxan-5-yl, a C1-6 alkyl group, a C3-8 cycloalkyl group, a C5-7 cycloalkenyl group or an (optionally substituted phenyl)C1-6 alkyl gr
SUBSTITUTED 4-AMINO-7H-PYRROLO [2,3,D]-PYRIMIDINES AS PTK INHIBITORS
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, (2008/06/13)
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