21384-53-2

Basic information

• Product Name: Methyl 1-benzyl-2-aziridinecarboxylate
• Synonyms: 1-(benzyl)ethylenimine-2-carboxylic acid methyl ester;1-(phenylmethyl)-2-aziridinecarboxylic acid methyl ester;1-Benzyl-2-carbomethoxyaziridine;methyl 1-(phenylmethyl)aziridine-2-carboxylate;Methyl 1-benzyl-2-aziridinecarboxylate;methyl 1-benzylaziridine-2-carboxylate
• CAS NO: 21384-53-2
• Molecular Weight: 191.23
• Mol File: 21384-53-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methyl 1-benzyl-2-aziridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-benzyl-2-aziridinecarboxylate(21384-53-2)
• EPA Substance Registry System: Methyl 1-benzyl-2-aziridinecarboxylate(21384-53-2)

Safety Data

• Hazardous Substances Data: 21384-53-2(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 53386-64-4 methyl 2-(benzylamino)acetate 
• 1729-67-5 Methyl 2,3-dibromopropionate 
• 100-44-7 benzyl chloride 
• 5950-34-5 methyl aziridine-2-carboxylate 
• 113729-05-8 3-benzyloxazolidine-4-carboxylate de methyle 

Downstream Products

• 36857-15-5 α-Chlor-β-benzylaminopropionsaeuremethylester 
• 36857-16-6 β-Chlor-α-benzylaminopropionsaeuremethylester 
• 141366-40-7 1-benzyl-(2RS)-(methoxycarbonyl)pyrrolidine-(3SR,4RS)-diyl carbonate 
• 141366-40-7 1-benzyl-(2SR)-(methoxycarbonyl)pyrrolidine-(3SR,4RS)-diyl carbonate 
• 176502-69-5 (+/-)-N-benzyl aziridine carboxylate t-butyl ester 
• 140887-47-4 2-benzylamino-3-methoxy-1-propanol 
• 108072-03-3 (2R,3S,4R)-1-Benzyl-4-isopropenyl-3-methoxycarbonylmethyl-pyrrolidine-2-carboxylic acid methyl ester 
• 108072-02-2 (2R,3S,4R)-1-Benzyl-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-4-isopropenyl-pyrrolidine-2-carboxylic acid methyl ester 
• 1026023-08-4 methyl 1-benzyl-2-(1-benzylaziridine-2-carbonyl)aziridine-2-carboxylate 
• 103912-39-6 1-benzylaziridine-2-carboxylic acid dimethylamide 
• 30005-72-2 1-benzyl-2-aziridine carboxaldehyde 
• 912338-21-7 C₂₂H₂₆N₂O 
• 133627-50-6 (3R,3aS,7aR)-1,6-Dibenzyl-3-(2-benzyloxy-ethyl)-octahydro-pyrrolo[2,3-c]pyridin-7-one 
• 133627-56-2 (1S,4S,7S,8R)-6-Benzyl-11-(toluene-4-sulfonyl)-2-vinyl-6,11-diaza-tricyclo[5.4.0.0^4,8]undecane 

Relevant articles and documents

Method for preparing beta arylamine

The invention discloses a method for preparing beta arylamine. The method includes mixing an aziridine compound, halogenated aromatic hydrocarbon, an oxidizing agent, a reducing agent and an organic solvent to obtain a mixed solution and obtaining the beta arylamine after reaction. The oxidizing agent is at least one of a mixture of nickel iodide and bipyridine, a mixture of nickel chloride dimethoxyethane and bipyridine and 2,2'-bipyridinium nickel iodide. The reducing agent is at least one of zinc powder, manganese powder, iron powder, cobalt powder, titanium powder, calcium powder and tetrakis(dimethylamino)ethylene. The halogenated aromatic hydrocarbon is at least one of the chlorinated aromatic hydrocarbon, the brominated aromatic hydrocarbon and aryl iodide. An organometallic reagentis not required, the preparation process is simple and reliable and high in yield, and the aziridine compound is wide in selection range.

A facile preparation of an octahydropyrrolo[2,3-c]pyridine enantiomer

A facile synthesis of octahydro-pyrrolo[2,3-c]pyridine 1 using an intramolecular [3+2]-cycloaddition of an azomethine ylide as the key step and employing DW-therm heat-transfer fluid as a solvent is disclosed. Enantiomerically pure 1 was obtained either via a chromatographic separation of the diastereoisomers 12 and 13 resulting from the cycloaddition with a chiral appendage or by a classical resolution of racemate 19.

Organic compounds

Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I