21394-91-2Relevant articles and documents
Repurposing de novo designed entities reveals phosphodiesterase 3B and cathepsin L modulators
Rodrigues, Tiago,Lin, Yen-Chu,Hartenfeller, Markus,Renner, Steffen,Lim, Yi Fan,Schneider, Gisbert
, p. 7478 - 7481 (2015)
Using computational bioactivity prediction models we identified phosphodiesterase 3B (PDE3B) and cathepsin L as macromolecular targets of de novo designed compounds. By disclosing the most potent cathepsin L activator known to date, small molecule repurposing by target panel prediction represents a feasible route towards innovative leads for chemical biology and molecular medicine. This journal is
Novel hydrazone derivatives comprising aryl or heteroaryl group substituted at terminal amine and use thereof
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Paragraph 2086; 2088-2090, (2020/08/28)
The present invention relates to novel hydrazone derivatives with an aryl or heteroaryl group substituted at a terminal amine group thereof and a use thereof.
6-Aryl-4,5-dihydro-3(2H)-pyridazinones. A new class of compounds with platelet aggregation inhibiting and hypotensive activities
Thyes,Lehmann,Gries,Koenig,Kretzschmar,Kunze,Lebkuecher,Lenke
, p. 800 - 807 (2007/10/02)
This paper reports on the synthesis and pharmacological activity of 6-aryl-4,5-dihydro-3(2H)-pyridazinone derivatives. The compounds exhibit an aggregation inhibiting action on human platelets in vitro and on rat platelets under ex vivo conditions, as wel