213999-88-3Relevant articles and documents
Structural exploration of cinnamate-based phosphonic acids as inhibitors of bacterial ureases
Ntatsopoulos, Vassilis,Macegoniuk, Katarzyna,Mucha, Artur,Vassiliou, Stamatia,Berlicki, ?ukasz
, p. 307 - 316 (2018/10/15)
The conjugated system of cinnamic acid, α-substituted with a phosphonoalkyl residue, was previously validated as a scaffold that provided one of the most potent organophosphorus inhibitors of bacterial urease. Following the idea of using Morita-Baylis-Hil
Allylic isothiouronium salts: The discovery of a novel class of thiourea analogues with antitumor activity
Ferreira, Misael,Assun??o, Laura Sartori,Silva, Adny Henrique,Filippin-Monteiro, Fabíola Branco,Creczynski-Pasa, Tania Beatriz,Sá, Marcus Mandolesi
, p. 151 - 158 (2017/02/26)
A series of 28 aryl- and alkyl-substituted isothiouronium salts were readily synthesized in high yields through the reaction of allylic bromides with thiourea, N-monosubstituted thioureas or thiosemicarbazide. The S-allylic isothiouronium salts substitute
Synthesis of thio-heterocyclic analogues from Baylis-Hillman bromides as potent cyclooxygenase-2 inhibitors
Santhoshi, Amlipur,Mahendar, Budde,Mattapally, Saidulu,Sadhu, Partha Sarathi,Banerjee, Sanjay Kumar,Jayathirtha Rao, Vaidya
, p. 1952 - 1957 (2014/04/17)
A series of thio-substituted pyrimidine, benzoxazole, benzothiazole and triazole analogues were synthesized from Baylis-Hillman bromides in a clean and efficient way. The synthesized twenty new compounds were subjected to in vitro COX-1 and COX-2 inhibito
