2141-09-5 Usage
Description
(+)-Magnoflorine Iodide is a quaternary alkaloid that is widely found in various species, particularly in the families Aquilegia, Magnolia, and Michelia. It has been isolated and characterized as the iodide with a melting point of 248-249°C (decomposition) and a specific rotation of +200.1° (MeOH). The optically inactive base also yields an iodide which crystallizes with 1.5 H2O, with a melting point of 243°C (decomposition). Magnoflorine is a major constituent of S. acutum and exhibits diverse biological activities.
Uses
Used in Pharmaceutical Industry:
(+)-Magnoflorine Iodide is used as a pharmaceutical compound for its diverse biological activities. It is effective in reducing hemolysis induced by lysophosphatidylcholine (LPC) in rat erythrocyte suspensions at concentrations ranging from 0.01 to 10 μM. This property makes it a potential candidate for treating conditions related to erythrocyte damage.
Used in Neurological Applications:
(+)-Magnoflorine Iodide is used as a neuromodulatory agent, as it induces intracellular chloride influx in neuroblastoma cells at a concentration of 10 μM. This effect can be reversed by the GABAA receptor antagonist bicuculline, suggesting its potential use in treating neurological disorders related to chloride transport and GABAergic signaling.
Used in Anti-inflammatory Applications:
(+)-Magnoflorine Iodide is used as an anti-inflammatory agent, as it reduces TNF-α-induced NF-κB expression as well as the production of IL-6 and IL-8 in BEAS-2B cells. This indicates its potential use in treating inflammatory conditions by modulating the immune response.
Used in Cognitive Enhancement:
(+)-Magnoflorine Iodide is used as a cognitive enhancer, as it improves shortand long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment at a dosage of 20 mg/kg, administered intraperitoneally. This suggests its potential use in treating cognitive disorders and enhancing memory function.
References
Nakano., Chem. Pharm. Bull. (Tokyo), 2, 329 (1954)
Tomita, Kikkawa.,J. Pharm. Soc., Japan, 77, 195 (1957)
Gopinath et aI., J. Sci. Ind. Res., 18B, 444 (1959)
Ishii, Harada.,J. Pharm. Soc., Japan, 81,238 (1961)
Yang, Lu, Hsiao., ibid, 82,794,816 (1962)
Yang, Lu, Hsiao., ibid, 83,216 (1963)
Check Digit Verification of cas no
The CAS Registry Mumber 2141-09-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,4 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2141-09:
(6*2)+(5*1)+(4*4)+(3*1)+(2*0)+(1*9)=45
45 % 10 = 5
So 2141-09-5 is a valid CAS Registry Number.
InChI:InChI=1/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1
