214134-72-2

Basic information

• Product Name: 4-amino-7-(3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-β-D-allofuranosyl)-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine
• CAS NO: 214134-72-2
• Molecular Weight: 751.553
• Mol File: 214134-72-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-7-(3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-β-D-allofuranosyl)-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-7-(3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-β-D-allofuranosyl)-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine(214134-72-2)
• EPA Substance Registry System: 4-amino-7-(3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-β-D-allofuranosyl)-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine(214134-72-2)

Safety Data

• Hazardous Substances Data: 214134-72-2(Hazardous Substances Data)

Upstream product

• 214134-63-1 methyl 3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-α,β-D-allofuranoside 
• 214134-61-9 3-azidomethyl-5,6-di-O-benzoyl-3-deoxy-1,2-O-isopropylidene-α-D-allofuranose 
• 214134-62-0 methyl 3-azidomethyl-5,6-di-O-benzoyl-3-deoxy-α,β-D-allofuranoside 
• 69832-48-0 ((3aR,5S,6R,6aR)-tetrahydro-2,2-dimethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)furo[2,3-d][1,3]dioxol-6-yl)methanol 
• 19393-83-0 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine 
• 214134-65-3 1-O-acetyl-3-azidomethyl-2,5,6-tri-O-benzoyl-3-deoxy-β-D-allofuranose 
• 214134-59-5 3-C-azidomethyl-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-allofuranose 
• 214134-60-8 3-C-azidomethyl-3-deoxy-1,2-O-isopropylidene-α-D-allofuranose 
• 180403-62-7 3-deoxy-1,2:5,6-di-O-isopropylidene-3-C-methanesulfonyloxymethyl-α-D-allofuranose 

Relevant articles and documents

Synthesis and in vitro antitumor activity of some amino-deoxy 7-hexofuranosylpyrrolo[2,3-d] pyrimidines

7-(6-amino-6-deoxy-β-D-glucofuranosyl)-5-cyanopyrrolo[2,3-d]pyrimidine (22) and 7-(3-aminomethyl-3-deoxy-β-D-allofuranosyl)-5-cyanpyrrolo[2,3-d]pyrimidine (28) were synthesized by sequentially coupling silylated 4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine with the corresponding protected sugars 9 and 17, followed by deblocking and catalytic hydrogenation. Conversion of the 5-nitrile in 22 and 28 into a carboxamide gave the corresponding sangivamycin derivatives 23 and 29. Whereas 5'-aminomethyl nucleosides 22 and 23 inhibited the growth of four different human tumor cell lines at μM concentrations, the 3'-aminomethyl analogs 28 and 29 were much less active against these cells.