21419-48-7

Basic information

• Product Name: 6-BROMO-QUINAZOLIN-4-YLAMINE
• Synonyms: 6-bromo-4-quinazolinamine;CHEMBRDG-BB 4022407;6-BROMOQUINAZOLIN-4-AMINE;6-BROMO-QUINAZOLIN-4-YLAMINE;4-quinazolinamine, 6-bromo-;6-bromoquinazolin-4-amine(SALTDATA: FREE);4-AMino-6-broMoquinazoline
• CAS NO: 21419-48-7
• Molecular Formula: C₈H₆BrN₃
• Molecular Weight: 224.06
• Mol File: 21419-48-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: >350 °C
• Boiling Point: 385.4 °C at 760 mmHg
• Flash Point: 186.9 °C
• Appearance: /
• Density: 1.744 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• PKA: 7.04±0.50(Predicted)
• CAS DataBase Reference: 6-BROMO-QUINAZOLIN-4-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-QUINAZOLIN-4-YLAMINE(21419-48-7)
• EPA Substance Registry System: 6-BROMO-QUINAZOLIN-4-YLAMINE(21419-48-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 21419-48-7(Hazardous Substances Data)

Usage

General Description

6-Bromo-quinazolin-4-ylamine is a chemical compound with the molecular formula C8H6BrN3. It is a derivative of quinazoline and is commonly used in the pharmaceutical industry for the synthesis of potential drug candidates. 6-BROMO-QUINAZOLIN-4-YLAMINE has been found to exhibit anti-cancer and anti-inflammatory properties, making it a promising candidate for the development of novel therapeutic agents. Its chemical structure and properties make it a valuable building block for the synthesis of biologically active molecules, and it is also used as a research tool in the study of various biochemical pathways and disease processes. Overall, 6-Bromo-quinazolin-4-ylamine is a valuable chemical with potential applications in both medicinal chemistry and biological research.

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 77287-34-4 formamide 
• 304858-65-9 2-amino-4-bromobenzonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 38267-96-8 6-bromo-4-chloroquinozoline 

Downstream Products

• 1003025-54-4 6-(4-fluorophenyl)quinazolin-4-amine 

Relevant articles and documents

An organometallic inhibitor for the human repair enzyme 7,8-dihydro-8-oxoguanosine triphosphatase

The probe-based discovery of the first small-molecule inhibitor of the repair enzyme 8-oxo-dGTPase (MTH1) is presented, which is an unconventional cyclometalated ruthenium half-sandwich complex. The organometallic inhibitor with low-nanomolar activity displays astonishing specificity, as verified in tests with an extended panel of protein kinases and other ATP binding proteins. The binding of the organometallic inhibitor to MTH1 is investigated by protein crystallography. Not a canonical inhibitor: A ruthenium complex has been shown to be a low-nanomolar and selective inhibitor of an enzyme that hydrolyzes oxidized purine nucleoside triphosphates. This work provides a blueprint for the discovery and development of organometallic inhibitors of other purine nucleotide binding proteins which rely on ruthenium-coordinated adenine and quinazoline derivatives with tailored coordination spheres. Copyright

Microwave-assisted thermal decomposition of formamide: A tool for coupling a pyrimidine ring with an aromatic partner

Rapid and efficient generation of CO and NH3 in the reaction mixture via microwave-assisted thermal decomposition of formamide may represent a significant improvement over existing methods for coupling a pyrimidine ring with an aromatic partner. This work aims at alerting readers on the probability to observe interesting phenomena and reactions when this very powerful heating mode is associated with thermally unstable reagents.