214210-30-7

Basic information

• Product Name: 4-Bromo-2-fluorobenzenesulfonamide
• Synonyms: 4-Bromo-2-fluorobenzenesulfonamide;4-broMo-2-fluorobenzene-1-sulfonaMide
• CAS NO: 214210-30-7
• Molecular Formula: C₆H₅BrFNO₂S
• Molecular Weight: 254.08
• Product Categories: Fluorobenzene;Benzenes;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds
• Mol File: 214210-30-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 356.086 °C at 760 mmHg
• Flash Point: 169.155 °C
• Appearance: /
• Density: 1.831 g/cm³
• Vapor Pressure: 0.038mmHg at 25°C
• Refractive Index: 1.506
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.50±0.60(Predicted)
• CAS DataBase Reference: 4-Bromo-2-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-fluorobenzenesulfonamide(214210-30-7)
• EPA Substance Registry System: 4-Bromo-2-fluorobenzenesulfonamide(214210-30-7)

Safety Data

• Hazard Codes: Xi
• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 214210-30-7(Hazardous Substances Data)

Usage

General Description

4-Bromo-2-fluorobenzenesulfonamide is a chemical compound with the molecular formula C6H5BrFNO2S. It is a white solid that is soluble in organic solvents and exhibits sulfonamide group characteristics. 4-Bromo-2-fluorobenzenesulfonamide is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used in research and development processes in the chemical industry. Additionally, 4-Bromo-2-fluorobenzenesulfonamide has been studied for its potential antimicrobial and anti-inflammatory properties, making it a subject of interest in the development of new therapeutic agents.

InChI:InChI=1/C9H8ClFO2/c1-13-9(12)4-6-2-3-7(11)5-8(6)10/h2-3,5H,4H2,1H3

Upstream product

• 216159-03-4 4-bromo-2-fluorobenzenesulfonyl chloride 

Downstream Products

• 491876-10-9 4-bromo-N-(4,4'-dimethoxytrityl)-2-fluorobenzenesulfonamide 
• 30058-40-3 2-fluorobenzenesulfonamide 
• 491876-03-0 C₂₇H₂₅BFNO₆S 
• 855481-98-0 4-bromo-2-(cyclohexyloxy)benzenesulfonamide 
• 1204573-63-6 4-bromo-2-(cyclopropylamino)benzenesulfonamide 

Relevant articles and documents

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

AMINOALCOHOL DERIVATIVES

The present invention relates to a compound of the formula [I]: wherein (a), in which -Y-, R4, R5 and R6 are4 R5each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20 R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, -S-, R9 -SO- or -SO2-, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is -CONHSO2- or -S02NHCO-, E is bond or lower alkylene, and R10is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.