214287-66-8Relevant articles and documents
Structural and Rate Studies of the 1,2-Additions of Lithium Phenylacetylide to Lithiated Quinazolinones: Influence of Mixed Aggregates on the Reaction Mechanism
Briggs, Timothy F.,Winemiller, Mark D.,Collum, David B.,Parsons Jr., Rodney L.,Davulcu, Akin H.,Harris, Gregory D.,Fortunak, Joseph M.,Confalone, Pat N.
, p. 5427 - 5435 (2004)
The 1,2-addition of lithium phenylacetylide (PhCCLi) to quinazolinones was investigated using a combination of structural and rate studies. 6Li, 13C, and 19F NMR spectroscopies show that deprotonation of quinazolinones and
Inhibition of clinically relevant mutant variants of HIV-1 by quinazolinone non-nucleoside reverse transcriptase inhibitors
Corbett, Jeffrey W.,Ko, Soo S.,Rodgers, James D.,Gearhart, Lisa A.,Magnus, Nicholas A.,Bacheler, Lee T.,Diamond, Sharon,Jeffrey, Susan,Klabe, Ronald M.,Cordova, Beverly C.,Garber, Sena,Logue, Kelly,Trainor, George L.,Anderson, Paul S.,Erickson-Viitanen, Susan K.
, p. 2019 - 2030 (2007/10/03)
A series of 4-alkenyl and 4-alkynyl-3,4-dihydro-4-(trifluoromethyl)-2- (1H)-quinazolinones were found to be potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) of human immunodeficiency virus type-1 (HIV-1). The 4-alkenyl-3,4-dihydro-4-(triflu