214288-97-8

Basic information

• Product Name: Benzoic acid, 2-[(aminocarbonyl)amino]-4-chloro-
• CAS NO: 214288-97-8
• Molecular Formula: C8H7ClN2O3
• Molecular Weight: 214.608
• Mol File: 214288-97-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-[(aminocarbonyl)amino]-4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-[(aminocarbonyl)amino]-4-chloro-(214288-97-8)
• EPA Substance Registry System: Benzoic acid, 2-[(aminocarbonyl)amino]-4-chloro-(214288-97-8)

Safety Data

• Hazardous Substances Data: 214288-97-8(Hazardous Substances Data)

Upstream product

• 590-28-3 potassium cyanate 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 917-61-3 sodium isocyanate 

Downstream Products

• 112733-28-5 ethyl 2-[3-(4-bromo-2-fluorobenzyl)-7-chloro-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-1-yl)acetate 
• 112733-06-9 zenarestat 
• 112733-45-6 ethyl 2-(7-chloro-1,2,3,4-tetrahydro-2,4-dioxoquinazoline-1-yl)acetate 
• 6625-94-1 2,4,7-trichloroquinazoline 
• 13165-35-0 7-chloroquinazoline-2,4-dione 

Relevant articles and documents

Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water

An efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones was developed. First, the reactions of anthranilic acid derivatives with potassium cyanate afforded the corresponding urea derivatives. Then, cyclization of the urea derivatives with NaOH afforded the monosodium salts of benzoylene urea. Finally, HCl treatment afforded the desired products in near-quantitative yields. This is an eco-efficient method because all the reactions were carried out in water, and the desired products were obtained simply by filtration. The aqueous filtrate was the only waste generated from the reaction. We scaled up the reaction to 1 kg starting material, thus establishing an alternative approach for the green synthesis of quinazoline-2,4(1H,3H)-diones in the chemical and pharmaceutical industries.