21436-98-6 Usage
Description
2,6-Dimethylaniline hydrochloride is an organic compound with the chemical formula C8H12N?HCl. It is a derivative of aniline, featuring two methyl groups at the 2nd and 6th positions on the benzene ring. 2,6-DIMETHYLANILINE HYDROCHLORIDE is a white or off-white crystalline solid and is known for its reactivity and various applications in the chemical industry.
Uses
Used in Chemical Synthesis:
2,6-Dimethylaniline hydrochloride is used as a starting material for the preparation of 2,6-dimethylphenyl isocyanate via phosgenation. This isocyanate compound is an important intermediate in the production of various chemicals, including polyurethanes, which are widely used in the manufacturing of flexible and rigid foams, adhesives, coatings, and elastomers.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,6-dimethylaniline hydrochloride may be utilized as an intermediate for the synthesis of various pharmaceutical compounds. Its reactivity and structural properties make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Dye and Pigment Industry:
2,6-Dimethylaniline hydrochloride can also be used in the dye and pigment industry for the production of organic dyes and pigments. Its chemical structure allows for the creation of a range of colors and hues, which can be applied in various applications such as textiles, plastics, and printing inks.
Used in Laboratory Research:
Due to its reactivity and unique chemical properties, 2,6-dimethylaniline hydrochloride is often used in laboratory research for the synthesis of various organic compounds and the study of chemical reactions. It serves as a valuable tool for chemists and researchers in understanding the behavior of similar compounds and developing new synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 21436-98-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,3 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21436-98:
(7*2)+(6*1)+(5*4)+(4*3)+(3*6)+(2*9)+(1*8)=96
96 % 10 = 6
So 21436-98-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H11N.ClH/c1-6-4-3-5-7(2)8(6)9;/h3-5H,9H2,1-2H3;1H
21436-98-6Relevant articles and documents
Mild N-deacylation of secondary amides by alkylation with organocerium reagents
Wang, Ai-E.,Chang, Zong,Liu, Yong-Peng,Huang, Pei-Qiang
supporting information, p. 1055 - 1058 (2015/09/01)
Secondary amides are a class of highly stable compounds serving as versatile starting materials, intermediates and directing groups (amido groups) in organic synthesis. The direct deacylation of secondary amides to release amines is an important transformation in organic synthesis. Here, we report a protocol for the deacylation of secondary amides and isolation of amines. The method is based on the activation of amides with Tf2O, followed by addition of organocerium reagents, and acidic work-up. The reaction proceeded under mild conditions and afforded the corresponding amines, isolated as their hydrochloride salts, in good yields. In combination with the C-H activation functionalization methodology, the method is applicable to the functionalization of aniline as well as conversion of carboxylic derivatives to functionalized ketones.
Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4
MacNair, Alistair J.,Tran, Ming-Ming,Nelson, Jennifer E.,Sloan, G. Usherwood,Ironmonger, Alan,Thomas, Stephen P.
supporting information, p. 5082 - 5088 (2014/07/08)
An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron(iii) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This reaction has been applied to the reduction of terminal alkenes (22 examples, up to 95% yield) and nitro-groups (26 examples, up to 95% yield). Deuterium labelling studies indicate that this reaction proceeds via an ionic rather than radical mechanism.
Synthesis of primary amines by the electrophilic amination of Grignard reagents with 1,3-dioxolan-2-one O-sulfonyloxime
Kitamura, Mitsuru,Suga, Takahiro,Chiba, Shunsuke,Narasaka, Koichi
, p. 4619 - 4621 (2007/10/03)
(Chemical equation presented) Primary amines are prepared by the electrophilic amination of Grignard reagents with 4,4,5,5-tetramethyl-1,3- dioxolan-2-one O-phenylsulfonyloxime and the acidic hydrolysis of the resulting imines.
