21438-63-1

Basic information

• Product Name: H-TRP-MET-OH
• Synonyms: H-TRP-MET-OH
• CAS NO: 21438-63-1
• Molecular Formula: C16H21N3O3S
• Molecular Weight: 335.42
• Mol File: 21438-63-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 689.6±55.0 °C(Predicted)
• Appearance: /
• Density: 1.327±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 3.06±0.10(Predicted)
• CAS DataBase Reference: H-TRP-MET-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-TRP-MET-OH(21438-63-1)
• EPA Substance Registry System: H-TRP-MET-OH(21438-63-1)

Safety Data

• Hazardous Substances Data: 21438-63-1(Hazardous Substances Data)

Usage

General Description

H-TRP-MET-OH, also known as hydroxytryptophan-methionine-alcohol, is a chemical compound that consists of the amino acids tryptophan and methionine. It is commonly used in the field of biochemistry and pharmaceutical research as a building block for peptides and proteins, and as a substrate for enzyme assays. H-TRP-MET-OH can also be used in the synthesis of pharmaceutical drugs and in the development of novel therapeutic agents. It has potential applications in the treatment of various diseases and conditions, including neurological disorders, cancer, and metabolic disorders. Overall, H-TRP-MET-OH plays an important role in the advancement of medical science and drug discovery.

Upstream product

• 1947-37-1 cholecystokinin-4 

Relevant articles and documents

Solid-state stability studies of cholecystokinin (CCK-4) peptide under nonisothermal conditions using thermal analysis, chromatography and mass spectrometry

The solid-state stability of cholecystokinin (CCK-4) peptide under nonisothermal conditions was studied by differential scanning calorimetry (DSC), chromatography and mass spectrometry, identifying and schematizing the degradation products. To model the degradation mechanism of the peptide using the combined Kissinger and direct-differential methods, the observed degradation process was characterized by decomposition temperature (Tm), reacted fraction (αm), activation energy (Ea), and pre-exponential factor (A). Results obtained by the two calculation methods were similar. The cleavage reaction on both N- and C-terminal sides of aspartic acid was the principal degradation pathway, although the reaction can occur consecutively and/or in parallel. Therefore to determine the relative importance of the different degradation pathways, a system of differential equations relevant to each degradation reaction was analysed using the R statistical program. The results obtained show that the consecutive reaction was the less plausible, whereas a slightly better fit was obtained for the reaction with both processes than for the in-parallel reaction. In this situation, the F-test was applied to discriminate between the models, indicating that the simpler model is the most probable. In conclusion, the results demonstrate for the first time that, in solid-state, n - 1 cleavage occurs in parallel to n + 1 cleavage at aspartic acid residues and not consecutively.