21441-89-4

Basic information

• Product Name: (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)propionic acid
• Synonyms: (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)propionic acid
• CAS NO: 21441-89-4
• Molecular Weight: 294.307
• Mol File: 21441-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)propionic acid(21441-89-4)
• EPA Substance Registry System: (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)propionic acid(21441-89-4)

Safety Data

• Hazardous Substances Data: 21441-89-4(Hazardous Substances Data)

Upstream product

• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 19914-26-2 (R)-2-(2-(R)-(benzyloxy(carbonyl)amino)propionylamino)methyl propionate 
• 57355-13-2 N-benzyloxycarbonylalaninehydrazid 
• 79411-36-2 Z-D-Ala-D-Ala-OEt 

Downstream Products

• 923-16-0 D-alanyl-D-alanine 

Relevant articles and documents

SPECIFICALLY ACTIVATED MICROMOLECULAR TARGET COUPLING BODY IN TUMOR MICROENVIRONMENT AND USE THEREOF

Provided are an anticancer compound comprising a cleavable linker specifically activated in a tumor microenvironment, and use thereof. The anticancer compound is represented by the following formula, wherein, R1 is a normal functional group or a protection group; R2 is Ala, Thr, Val or Ile; R3 is Ala, Val or Asn; R4 is a drug group linked via a hydroxyl group or an amino group; and the general formula of the drug is R4H. The anticancer compound is only activated at a local portion of a tumor, thus avoiding the defect of immune system damage of a traditional chemotherapeutic drug, and promoting tumor immunization by removing a tumor immunosuppression cell. The anticancer compound or pharmaceutical composition thereof is jointly used with immunotherapy, thus improving the effect of treating the tumor, and effectively inhibiting tumor metastasis and osseous metastasis.