21461-89-2 Usage
Description
(S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylic acid, also known as (S)-Methyl γ-ketotetrahydrofuran-2-carboxylate, is a chemical compound with the molecular formula C7H10O4. It is a carboxylic acid derivative characterized by its white to off-white solid appearance and solubility in organic solvents such as methanol, ethanol, and chloroform. (S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylicacid is recognized for its potential applications in the pharmaceutical industry, particularly in the synthesis of biologically active molecules and drug candidates. Its chiral nature also renders it valuable in asymmetric synthesis and chiral separation processes, making (S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylic acid a versatile and significant chemical compound in the realms of organic chemistry and pharmaceutical research.
Uses
Used in Pharmaceutical Industry:
(S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylic acid is used as a building block for the synthesis of various biologically active molecules and drug candidates. Its application is attributed to its unique chemical structure and reactivity, which facilitate the creation of novel compounds with potential therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, (S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylic acid is utilized as a key intermediate due to its carboxylic acid derivative nature, allowing for further functionalization and the development of a diverse range of organic compounds.
Used in Asymmetric Synthesis:
(S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylicacid is employed as a chiral building block in asymmetric synthesis, taking advantage of its optical activity to produce enantiomerically pure compounds, which are essential in the development of single-enantiomer drugs with improved efficacy and reduced side effects.
Used in Chiral Separation Processes:
(S)-2-Methyl-5-oxotetrahydrofuran-2-carboxylic acid is used in chiral separation processes to isolate and purify enantiomers, which is crucial for ensuring the purity and specificity of chiral drugs in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 21461-89-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,6 and 1 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21461-89:
(7*2)+(6*1)+(5*4)+(4*6)+(3*1)+(2*8)+(1*9)=92
92 % 10 = 2
So 21461-89-2 is a valid CAS Registry Number.
21461-89-2Relevant articles and documents
Asymmetric synthesis of 2-alkyl-substituted 2-hydroxyglutaric acid γ-lactones
Paju, Anne,Laos, Marit,J?gi, Artur,P?ri, Malle,J??laid, Raissa,Pehk, T?nis,Kanger, T?nis,Lopp, Margus
, p. 4491 - 4493 (2007/10/03)
3-Alkyl-1,2-cyclopentanediones 1 are transformed into 2-alkyl-2-hydroxyglutaric acid γ-lactones 3 in up to 83% isolated yields and up to 96% ee, affording a simple access to many bioactive compounds, including diacylglycerol lactones (DAG-lactones).
Asymmetric oxidation of 3-alkyl-1,2-cyclopentanediones. Part 1: 3-Hydroxylation of 3-alkyl-1,2-cyclopentanediones
Paju, Anne,Kanger, Tonis,Pehk, Tonis,Mueuerisepp, Aleksander-Mati,Lopp, Margus
, p. 2439 - 2448 (2007/10/03)
3-Alkyl-1,2-cyclopentanediones undergo asymmetric 3-hydroxylation with the Sharpless Ti-complex resulting in enantiomeric 3-hydroxy carbonyl compounds with ee up to 95% in yields of 22-40%.
Synthesis of optically active forms of frontalin. The pheromone of Dendroctonus bark beetles
Mori
, p. 1381 - 1384 (2007/10/04)
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