214630-04-3 Usage
Description
BOC-D-ASP-OFM is a chemical compound that belongs to the class of Boc-D-Aspartic acid derivatives. It is a derivative of aspartic acid with a Boc (tert-butyloxycarbonyl) protecting group and an OFM (9-fluorenylmethyloxycarbonyl) protecting group. BOC-D-ASP-OFM is characterized by its ability to protect the carboxyl group of aspartic acid during peptide synthesis, allowing for the controlled formation of peptide bonds and preventing unwanted side reactions.
Uses
Used in Pharmaceutical Industry:
BOC-D-ASP-OFM is used as a protecting group in peptide synthesis for the carboxyl group of aspartic acid. It is crucial for the development and production of peptides with specific biological and therapeutic properties. The Boc and OFM protecting groups ensure that the carboxyl group remains unreactive during the initial stages of peptide synthesis, and can be removed under mild conditions to reveal the free carboxyl group for further functionalization and the formation of the desired peptide sequence.
Used in Research and Development:
In the field of research and development, BOC-D-ASP-OFM is utilized for the synthesis of novel peptide-based compounds with potential applications in various therapeutic areas. Its role in protecting the carboxyl group of aspartic acid allows researchers to explore new peptide sequences and structures, leading to the discovery of innovative drugs and treatments.
Used in Biochemistry and Molecular Biology:
BOC-D-ASP-OFM is also employed in biochemical and molecular biology studies, where it aids in the synthesis of peptides for use as research tools or for understanding the fundamental processes of protein synthesis and folding. The controlled protection and deprotection of the carboxyl group enable the investigation of peptide interactions and the role of specific amino acid residues in protein function.
Check Digit Verification of cas no
The CAS Registry Mumber 214630-04-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,6,3 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 214630-04:
(8*2)+(7*1)+(6*4)+(5*6)+(4*3)+(3*0)+(2*0)+(1*4)=93
93 % 10 = 3
So 214630-04-3 is a valid CAS Registry Number.
214630-04-3Relevant articles and documents
Rediscovering an endothelin antagonist (BQ-123): A self-deconvoluting cyclic pentapeptide library
Spatola, Arno F.,Crozet, Yvon,DeWit, Damiane,Yanagisawa, Masashi
, p. 3842 - 3846 (1996)
A 'self-deconvoluting' cyclic pentapeptide library, designed to produce 82 944 head-to-tail-linked peptides in 48 vials, has been prepared. The mixture included amine acids found in a recently optimized endothelin antagonist, BQ-123, originally isolated from microbial sources by Banyu investigators. Using a positional scan approach, the most potent of 12 residues at each of the four variable positions uniquely rediscovered the BQ- 123 sequence or cyclo(L-Pro-D-Val-L-Leu-D-Trp-D-Asp). Resynthesis of the four most potent amine acid combinations gave the following values of relative potency: cyclo(L-Pro-D-Val-L-Leu-D-Trp-D-Asp) or BQ-123 = 1.0, cyclo(L-Pro- D-Pro-L-Leu-D-Trp-D-Asp) = 0.0, cyclo(L-Pro-D-Pro-L-Trp-D-Trp-D-Asp) = 0.0, and cyclo(L-Pro-D-Val-L-Trp-D-Trp-D-Asp) = 0.1. This study reflects the first time that the positional scan approach has been applied to cyclic peptide libraries using a known target. Although no analogs more potent than BQ-123 were discovered, our results provide verification of our synthetic methods for preparing head-to-tail cyclic peptide libraries and also lend support to the use of carefully designed sublibraries for the rapid elucidation of potential leads within a relatively constrained set of peptide macrocycles.