21478-95-5

Basic information

• Product Name: N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide
• Synonyms: N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide;N-(5-bromo-4-methyl-1,3-thiazol-2-yl)ethanamide;N-(5-bromo-4-methyl-2-thiazolyl)acetamide
• CAS NO: 21478-95-5
• Molecular Formula: C₆H₇BrN₂OS
• Molecular Weight: 235.10158
• Mol File: 21478-95-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide(21478-95-5)
• EPA Substance Registry System: N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide(21478-95-5)

Safety Data

• Hazardous Substances Data: 21478-95-5(Hazardous Substances Data)

Usage

General Description

N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is a chemical compound that contains a thiazole ring with a bromine and methyl group attached to it. It also has an acetamide group attached to the thiazole ring. N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It has demonstrated antifungal and antimicrobial properties, making it potentially useful in the development of new drugs and agricultural products. The presence of the thiazole ring in this compound also suggests that it may have other biological activities, such as anti-inflammatory or antioxidant properties. Overall, N-(5-bromo-4-methyl-1,3-thiazol-2-yl)acetamide is a versatile compound with potential applications in various fields of chemistry and biology.

Upstream product

• 7336-51-8 2-acetamido-4-methylthiazole 
• 3034-57-9 5-bromo-4-methyl-2-thiazolamine 
• 108-24-7 acetic anhydride 

Downstream Products

• 3034-57-9 5-bromo-4-methyl-2-thiazolamine 
• 874508-71-1 4-methyl-5-p-tolylsulfanyl-thiazol-2-ylamine 
• 54406-10-9 5-(4-chloro-phenylsulfanyl)-4-methyl-thiazol-2-ylamine 
• 7336-51-8 2-acetamido-4-methylthiazole 
• 593958-72-6 N-[5-(4-methanesulfonyl-phenyl)-4-methyl-thiazol-2-yl]-acetamide 

Relevant articles and documents

Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents

New derivatives of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124, 3), were synthesized as continuation to our previous patented efforts. Compounds 15 and 20 showed marginal hypnotic potency compared to 3. Compounds 15 (0.78 mmol/kg) and 20 (0.39 mmol/kg) showed remarkable 100% protection against PTZ induced convulsions with two and four fold increase in activity than sodium valproate (1.38 mmol/kg), respectively. Molecular modeling studies showed hydrogen bonding interaction between 15 and Thr56 residues at the binding site of GABAA. Superposition, flexible alignment and surface mapping of 15, 20 and diazepam supports their biological resemblance where ADMET study suggested that those compounds could be used as oral anticonvulsants.

5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS

Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.