215183-32-7

Basic information

• Product Name: (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one
• Synonyms: (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one
• CAS NO: 215183-32-7
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.27958
• EINECS: -0
• Mol File: 215183-32-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one(215183-32-7)
• EPA Substance Registry System: (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one(215183-32-7)

Safety Data

• Hazardous Substances Data: 215183-32-7(Hazardous Substances Data)

Usage

Description

(S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one, commonly known as R-phenibut, is a chemical compound with psychoactive properties. It is a derivative of the neurotransmitter GABA (gamma-aminobutyric acid) and is recognized for its potential to reduce anxiety, improve cognitive function, and enhance mood. However, it can also have sedative effects and may lead to dependence and withdrawal symptoms with long-term use. Due to its psychoactive properties, R-phenibut is regulated in some countries and may require a prescription or be prohibited for use without medical supervision.

Uses

Used in Pharmaceutical Applications:
(S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one is used as a nootropic for enhancing cognitive function, as it is believed to improve brain function and mental clarity.
Used in Anxiolytic Applications:
(S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one is used as an anxiolytic to help reduce anxiety and promote a sense of calm and relaxation.
Used in Sedative Applications:
(S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one is used as a sedative to induce sleep and help with insomnia.
Used in Recreational Applications:
(S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one is used recreationally for its mood-enhancing and relaxing effects, although it carries a moderate risk of abuse and is regulated in some countries.
Used in Medical Supervision:
Due to its potential for dependence and withdrawal symptoms, (S)-4-(hydroxyMethyl)-1-((R)-1-phenylethyl)pyrrolidin-2-one is used under medical supervision in some countries, where it may require a prescription for safe and controlled use.

Upstream product

• 252051-19-7 (4S,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde 

Downstream Products

• 252051-20-0 (4S,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one 
• 109960-55-6 (3S)-N-<(R)-phenylethyl>-3-(hydroxymethyl)pyrrolidine 
• 637014-33-6 (S)-4-Benzyloxymethyl-1-((R)-1-phenyl-ethyl)-pyrrolidin-2-one 
• 252051-25-5 (3S,1'R)-1-(1'-phenylethyl)-3-methanesulfonyloxymethylpyrrolidine 
• 252051-22-2 (3R,1'R)-1-(1'-phenylethyl)-3-naphthylaminomethylpyrrolidine 
• 252051-21-1 (4R,1'R)-1-(1'-phenylethyl)-4-naphthylaminomethylpyrrolidin-2-one 

Relevant articles and documents

New chiral 3-naphthylaminomethylpyrrolidines: An unexpected epimerisation reaction

New enantiomerically pure 3-naphthylaminomethylpyrrolidines (8), (9), (14) and (15) were obtained through simple steps starting from chiral 4- ethenylpyrrolidin-2-ones (2) and (3). On the other hand, starting from pyrrolidine (16), an epimerisation reacti