215248-42-3 Usage
Description
4'-(Fmoc-amino)-biphenyl-4-carboxylic acid, also known as 4'-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-[1,1'-biphenyl]-4-carboxylic Acid, is an organic compound that serves as a crucial building block in the synthesis of various biologically active molecules. It is characterized by its Fmoc-protected amino group and biphenyl core, which contribute to its structural and functional properties.
Uses
Used in Pharmaceutical Industry:
4'-(Fmoc-amino)-biphenyl-4-carboxylic acid is used as a building block for the preparation of vitronectin receptor antagonists, which are important in the development of therapeutic agents targeting various diseases, including cancer and inflammatory disorders. The Fmoc protection group ensures selective deprotection and coupling reactions during the synthesis process, allowing for precise control over the molecular structure of the final product.
Used in Research and Development:
In the field of research and development, 4'-(Fmoc-amino)-biphenyl-4-carboxylic acid is utilized as a key component in the synthesis of novel peptides, peptidomimetics, and other bioactive molecules. Its unique structure and functional groups enable the exploration of new chemical space and the development of innovative therapeutic strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, 4'-(Fmoc-amino)-biphenyl-4-carboxylic acid can also be incorporated into drug delivery systems to enhance its applications and efficacy. By employing various organic and metallic nanoparticles as carriers, the delivery, bioavailability, and therapeutic outcomes of molecules synthesized using this building block can be significantly improved.
Check Digit Verification of cas no
The CAS Registry Mumber 215248-42-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,5,2,4 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 215248-42:
(8*2)+(7*1)+(6*5)+(5*2)+(4*4)+(3*8)+(2*4)+(1*2)=113
113 % 10 = 3
So 215248-42-3 is a valid CAS Registry Number.
215248-42-3Relevant articles and documents
Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents
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, (2008/06/13)
The present invention provides compounds having the formula: wherein n is0or1; R is —NH2or wherein R1and R2are independently selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, carboxy, carboxyalkyl, and carbamoyl; Q is R3C(O)— or wherein R5is selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, and carbamoylalkyl, and R3and R4are selected from the group consisting of H, alkyl, alkoxy, arylalkoxy, aralkyl, heteroaralkyl, and carbamoylalkyl; the Q—NH—(CH2)n— and the —C(O)R substituents of the compound of formula I are independently positioned ortho, meta, orpara relative to the carbon atoms that form the bond between the two phenyl groups to which said substituents are bound, with the proviso that said substituents are not both positioned ortho; and the Q—NH—(CH2)nand the —C(O)R substituents of the compound of formula II are positioned meta orpara to each other; or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. The compounds are useful for treating uPA- or uPAR-mediated disorders, e.g., tumor metastasis, tumor angiogenesis, restenosis, chronic inflammation, or corneal angiogenesis.
