21539-55-9Relevant articles and documents
Effect of pressure on sterically hindered reactions with late transition states
Gacem, Badra,Jenner, Gerard
, p. 221 - 225 (2004)
The effect of high pressure is examined in two types of sterically congested reactions presenting late transition states: isopolar Diels-Alder cycloadditions of isoprene and quinones of various steric environment and conjugate additions of tert-butylamine and acrylic compounds. In the Diels-Alder cycloadditions, pressure has no enhanced kinetic sensitivity in sterically demanding reactions compared with unhindered ones. This is due to the structural closeness of the transition state and product. At variance, in the conjugate addition of amines, the effect of pressure is magnified with increasing steric congestion at the reaction centres. This is ascribed to enhanced electrostriction with removal of steric hindrance to ionization. Copyright
HISTAMINE H3 INVERSE AGONISTS AND ANTAGONISTS AND METHODS OF USE THEREOF
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Page/Page column 107, (2010/08/18)
Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
AMIDOPYRAZOLE DERIVATIVE
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Page/Page column 38-39, (2010/11/23)
A platelet coagulation inhibitor which inhibits neither COX-1 nor COX-2 is provided. The inhibitor is a compound represented by general formula (I): wherein Ar1 and Ar2 independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents, or a phenyl group optionally substituted with 1 to 3 substituents; R1 represents a lower acyl group, carboxyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted with 1 or 2 substituents, a carbamoyl group optionally substituted with 1 or 2 substituents, an oxamoyl group optionally substituted with 1 or 2 substituents, an amino group optionally substituted with 1 or 2 substituents, a 4- to 7-membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1 to 3 substituents, or a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1 to 3 substituents; and R2 represents hydrogen atom, a halogeno group, or the like.
