215611-55-5

Basic information

• Product Name: (S)-2-[(3-Benzyloxycarbonyl-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester
• Synonyms: (S)-2-[(3-Benzyloxycarbonyl-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester
• CAS NO: 215611-55-5
• Molecular Weight: 536.666
• Mol File: 215611-55-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[(3-Benzyloxycarbonyl-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(3-Benzyloxycarbonyl-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester(215611-55-5)
• EPA Substance Registry System: (S)-2-[(3-Benzyloxycarbonyl-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester(215611-55-5)

Safety Data

• Hazardous Substances Data: 215611-55-5(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 53229-60-0 4-oxobutanoic acid phenylmethyl ester 
• 113882-48-7 pent-4-enoic acid benzyl ester 
• 2389-48-2 N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride 

Downstream Products

• 215611-65-7 (S)-2-[(3-{[(S)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propyl]-hydroxy-carbamoyl}-propyl)-tert-butoxycarbonyl-amino]-6-tert-butoxycarbonylamino-hexanoic acid methyl ester 

Relevant articles and documents

Probing the activities and mechanisms of leukotriene A4 hydrolase with synthetic inhibitors

Leukotriene (LT) A4 hydrolase catalyzes the hydrolysis of leukotriene A4 to form leukotriene B4, a potent inflammatory mediator. Recently, the synthesis and evaluation of the highly effective competitive LTA4 hydrolase inhibitor 2 (K(i) = 1.6 nM) was described. In the present study, we describe the biological activity of 2 against LTB4 biosynthesis, as well as the design, synthesis, and evaluation of a new series of inhibitors intended to probe the active site of the enzyme. On the basis of these results and of previously reported site-directed mutagenesis and inhibition studies, the mechanisms of peptide and epoxide hydrolysis catalyzed by LTA4 hydrolase are discussed.