21603-70-3 Usage
Description
3-(2-Ethoxycarbonylethyl)-2,4-dimethyl-5-formylpyrrole is a pyrrole derivative with the molecular formula C13H17NO3. It features an ethoxycarbonyl group at the two-position and a formyl group at the five-position of the pyrrole ring, along with two methyl groups at the two and four positions. This chemical compound is known for its unique structural features and potential pharmacological activities, making it a valuable asset in organic synthesis and medicinal chemistry research.
Uses
Used in Organic Synthesis:
3-(2-Ethoxycarbonylethyl)-2,4-dimethyl-5-formylpyrrole is used as a key intermediate in organic synthesis for the development of various chemical compounds. Its unique structure allows for the creation of a wide range of molecules with different properties and applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-(2-Ethoxycarbonylethyl)-2,4-dimethyl-5-formylpyrrole is utilized as a building block for the design and synthesis of new pharmaceuticals. Its specific biological and chemical properties contribute to the discovery of potential drug candidates with novel mechanisms of action.
Used in the Development of Pharmaceuticals:
3-(2-Ethoxycarbonylethyl)-2,4-dimethyl-5-formylpyrrole plays a crucial role in the development of new pharmaceuticals, as its structural features can be manipulated to create molecules with desired therapeutic effects. 3-(2-ETHOXYCARBONYLETHYL)-2,4-DIMETHYL-5-FORMYLPYRROLE serves as a valuable tool for researchers working on the next generation of medicines.
Used in Agrochemical Development:
This pyrrole derivative is also employed in the development of agrochemicals, where its unique properties can be harnessed to create new compounds with applications in agriculture, such as pesticides or herbicides, to improve crop protection and yield.
Check Digit Verification of cas no
The CAS Registry Mumber 21603-70-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,0 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21603-70:
(7*2)+(6*1)+(5*6)+(4*0)+(3*3)+(2*7)+(1*0)=73
73 % 10 = 3
So 21603-70-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H17NO3/c1-4-16-12(15)6-5-10-8(2)11(7-14)13-9(10)3/h7,13H,4-6H2,1-3H3
21603-70-3Relevant articles and documents
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia
Jagtap, Ajit Dhananjay,Chang, Pei-Teh,Liu, Jia-Rong,Wang, Hsiao-Chun,Kondekar, Nagendra B.,Shen, Li-Jiuan,Tseng, Hsiang-Wen,Chen, Grace Shiahuy,Chern, Ji-Wang
, p. 268 - 288 (2014/08/18)
A series of 6-acylureido derivatives containing a 3-(pyrrol-2- ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2- one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2- fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2, 4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively). Compound 54 also exhibited potent cytotoxicity with single-digit nanomolar IC50 values against the FLT3 mutant-associated human acute myeloid leukemia (AML) cell lines MV4-11 (FLT3-ITD) and MOLM-13 (FLT3-ITD). Compound 54 also specifically induced extrinsic apoptosis by inhibiting the phosphorylation of the Aurora B and FLT3 pathways in MOLM-13 cells. Compound 54 had a moderate pharmacokinetic profile. The mesylate salt of 54 efficiently inhibited tumor growth and reduced the mortality of BALB/c nude mice (subcutaneous xenograft model) that had been implanted with AML MOLM-13 cells. Compound 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML.