2163-34-0

Basic information

• Product Name: 4-TERT-BUTYLCYCLOHEXANAMINE
• Synonyms: 4-TERT-BUTYLCYCLOHEXANAMINE;Trans-4-(Tert-Butyl)Cyclohexanamine;Cyclohexanamine, 4-(1,1-dimethylethyl)-, trans-;Trans-4-(Tert-Butyl)Cyclohexanamine(WXC00784)
• CAS NO: 2163-34-0
• Molecular Formula: C₁₀H₂₁N
• Molecular Weight: 155.28044
• Mol File: 2163-34-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 81-83 °C
• Boiling Point: 142-145 °C(Press: 19 Torr)
• Appearance: /
• Density: 0.861±0.06 g/cm3(Predicted)
• PKA: 10.58±0.70(Predicted)
• CAS DataBase Reference: 4-TERT-BUTYLCYCLOHEXANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYLCYCLOHEXANAMINE(2163-34-0)
• EPA Substance Registry System: 4-TERT-BUTYLCYCLOHEXANAMINE(2163-34-0)

Safety Data

• Hazardous Substances Data: 2163-34-0(Hazardous Substances Data)

Upstream product

• 4701-98-8 4-tert-butylcyclohexanone oxime 
• 943-29-3 trans-4-(tert-butyl)cyclohexane-1-carboxylic acid 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 943-27-1 4'-t-butylacetophenone 
• 98-73-7 4-(1,1-dimethylethyl)benzoic acid 
• 98-54-4 para-tert-butylphenol 
• 344869-42-7 N-(4-tert-butylcyclohexyl)benzylamine 
• 67498-86-6 trans-4-tert-butylcyclohexylbenzylamine 

Downstream Products

• 101866-18-6 2-[(trans-4-tert-Butyl-cyclohexylimino)-methyl]-phenol 
• 52755-78-9 N-(trans-4-tert.-Butylcyclohexyl)-sulfinylamin 
• 72087-46-8 N-Acetyl-N-m-chlorbenzoyl-trans-4-tert.-butylcyclohexylamin 
• 21862-63-5 trans-4-tert-butylcyclohexanol 
• 937-05-3 cis-4-tert-butyl-1-cyclohexanol 
• 85136-35-2 3,3-Dimethyl-butyric acid 4-tert-butyl-cyclohexyl ester 
• 85136-35-2 3,3-Dimethyl-butyric acid 4-tert-butyl-cyclohexyl ester 
• 1900-69-2 trans-4-tert-butylcyclohexyl acetate 
• 10411-92-4 cis-4-tert-butylcyclohexyl acetate 
• 78193-51-8 1-(4-tert-Butyl-cyclohexyl)-3-(2,2,2-trichloro-acetyl)-urea 
• 161465-33-4 ethyl trans-N-<4-(1,1-dimethylethyl)cyclohexyl>aminoacetate 
• 2523-69-5 trans-4-t-butyl-N,N-dimethylcyclohexylamine 
• 61965-95-5 N-(4-tert-Butyl-cyclohexyl)-3,3-diphenyl-propionamide 
• 13991-73-6 C₁₃H₂₄ClN₃O₂ 

Relevant articles and documents

6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS

The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.

Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates

The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl-tert-butylether), a non-ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized. (Figure presented.).

Aliphatic C-H Bond Oxidation with Hydrogen Peroxide Catalyzed by Manganese Complexes: Directing Selectivity through Torsional Effects

Substituted N-cyclohexyl amides undergo aliphatic C-H bond oxidation with H2O2 catalyzed by manganese complexes. The reactions are directed by torsional effects leading to site-selective oxidation of cis-1,4-, trans-1,3-, and cis-1,2-cyclohexanediamides. The corresponding diastereoisomers are unreactive under the same conditions. Competitive oxidation of cis-trans mixtures of 4-substituted N-cyclohexylamides leads to quantitative conversion of the cis-isomers, allowing isolation and successive conversion of the trans-isomers into densely functionalized oxidation products with excellent site selectivity and good enantioselectivity.