21639-21-4

Basic information

• Product Name: 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide
• CAS NO: 21639-21-4
• Molecular Weight: 274.343
• Mol File: 21639-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide(21639-21-4)
• EPA Substance Registry System: 2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide(21639-21-4)

Safety Data

• Hazardous Substances Data: 21639-21-4(Hazardous Substances Data)

Upstream product

• 16288-77-0 2-amino-N-methylbenzenesulfonamide 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

N-benzylation/benzylic C-H amidation cascade by the (ζ3- Benzyl)palladium system in aqueous media: An effective pathway for the direct construction of 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxides

We demonstrate a unique strategy for a benzylation/benzylic C-H amidation cascade reaction by the (ζ3-benzyl)palladium system derived from a palladium catalyst and benzyl alcohol. This tandem process is devised as a new synthetic route for 3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-1,1- dioxide. Water plays an important role for the smooth generation of the (ζ3-benzyl)palladium species, and a bis-benzylated Pd(II) intermediate would be formed in our catalytic system. Atom economical processes such as benzylic C-H activation, cascade reactions and chemoselective reactions in aqueous media have been developed.