2164-34-3

Basic information

• Product Name: 2-BROMOMETHYL-1,4-BENZODIOXANE
• Synonyms: TIMTEC-BB SBB003290;2-BROMOMETHYL-1,4-BENZODIOXAN;2-BROMOMETHYL-1,4-BENZODIOXANE;2-(BROMOMETHYL)-2,3-DIHYDRO-1,4-BENZODIOXINE;AKOS 90;2-(bromomethyl)-2,3-dihydro-1,4-benzodioxin;2-Bromomethyl-1,4-benzodioxane,97%;2-(broMoMethyl)-3,4-dihydro-2H-chroMene
• CAS NO: 2164-34-3
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• EINECS: 218-503-0
• Product Categories: Miscellaneous;BenzodioxanesHeterocyclic Building Blocks;Benzodioxanes;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 2164-34-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 250-251 °C(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to greyish or light yellow liquid
• Density: 1.533 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00409mmHg at 25°C
• Refractive Index: n20/D 1.5720(lit.)
• Storage Temp.: 2-8°C
• BRN: 150154
• CAS DataBase Reference: 2-BROMOMETHYL-1,4-BENZODIOXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOMETHYL-1,4-BENZODIOXANE(2164-34-3)
• EPA Substance Registry System: 2-BROMOMETHYL-1,4-BENZODIOXANE(2164-34-3)

Safety Data

• Hazard Codes: Xi,N
• Statements: 36-51/53
• Safety Statements: 26-60-61
• RIDADR: UN 3082 9/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 2164-34-3(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to greyish or light yellow liquid

InChI:InChI=1/C9H9BrO2/c10-5-7-6-11-8-3-1-2-4-9(8)12-7/h1-4,7H,5-6H2/t7-/m1/s1

Upstream product

• 3663-82-9 2-hydroxymethyl-2,3-dihydrobenzo[1,4]dioxin 
• 4739-94-0 ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate 
• 791-28-6 Triphenylphosphine oxide 
• 1034-39-5 dibromotriphenylphosphorane 

Downstream Products

• 129975-50-4 5-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 85076-06-8 axamozide 
• 18505-91-4 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)acetonitrile 
• 632-51-9 1,1,2,2-tetraphenylethylene 
• 1126-20-1 2-allyloxyphenol 
• 87086-36-0 2-(2,3-dihydrobenzo[1,4]dioxin-2-yl)ethylamine 

Relevant articles and documents

Design and synthesis of substituted compounds containing the 1,4- benzodioxin subunit. New potential calcium antagonists

New compounds possessing 1,4-benzodioxin or its saturated analogous heterocyclic system were synthesized and tested for calcium antagonist activity. Biological differences were seen between the different modifications applied. These compounds have been shown to be representative of a novel series of calcium channel antagonists. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

CERTAIN BENZODIOXOLE, BENZODIOXANE AND BENZODIOXEPIN DERIVATIVES USEFUL AS 5-LIPOXYGENASE INHIBITORS

The invention relates to the compounds of the formula wherein each R independently represents hydrogen, lower alkyl, halogen, trifluoromethyl, lower alkoxy, carbocyclic or heterocyclic aryl, carbocyclic or hetero-cyclic aryloxy, carbocyclic or heterocyclic aryl-lower alkyloxy, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyloxy, or Cs-Cv-cycloalk-yloxy; n represents 1, 2, 3 or 4; m represents 0, 1 or 2; A represents a direct bond or lower alkylene; X represents oxygen or sulfur; Ri represents hydrogen, acyl, lower alkoxycarbonyl, aminocarbonyl, mono- or di-lower alkylaminocarbonyl, lower alkenylaminocarbonyl, lower alkynylaminocarbonyl, carbocyclic or heterocy-clic aryl-lower alkylaminocarbonyl, carbocyclic or heterocyclic arylaminocarbonyl, C3-C7-cycloalk-ylaminocarbonyl or C3-C7-cycloalkyl-lower al-kylaminocarbonyl; R2 represents lower alkyl, lower alkoxycarbonyl-lower alkyl, C3-C7-cycloalkyl, carbo-cyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, C3-C7-cycloalkyl-lower alkyl, amino, mono- or di-lower alkylamino, lower alkenylamino, lower alkynylamino, carbocyclic or heterocyclic aryl-lower alkylamino, carbocyclic or heterocyclic arylamino, C3-C7-cycloalkylamino, C3-C7-cycloalkyl-lower alkylamino, lower alkoxycarbonyl-lower alkyl-amino or lower alkoxy; R3 and R4 independently repre-sent hydrogen or lower alkyl; and pharmaceuticallyacceptable salts thereof; which are useful as 5-lipoxyge-nase inhibitors.

9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones

Compounds useful in the prevention and/or treatment of hypertension, congestive heart failure, arrhythmia, migraine, vasospastic disorders, and asthma are represented by the formula: STR1 wherein: R1 is STR2 R2, R3, and R4 are independently hydrogen or lower alkyl of one to four carbon atoms; X is hydrogen, lower alkyl of one to four carbon atoms, lower alkoxy of one to four carbon atoms or halo; m is 1 or 2; and n is 1, 2 or 3; and the pharmaceutically acceptable acid addition salts thereof.