216443-25-3

Basic information

• Product Name: 3'-CHLORO-BIPHENYL-2-CARBALDEHYDE
• Synonyms: 3'-CHLORO-BIPHENYL-2-CARBALDEHYDE;3'-CHLORO[1,1'-BIPHENYL]-2-CARBALDEHYDE;3'-CHLORO-[1,1'-BIPHENYL]-2-CARBOXALDEHYDE;AKOS BAR-0182;2-chloro-6-phenylbenzaldehyde;3'-Chloro-biphenyl-2-carboxaldehyde
• CAS NO: 216443-25-3
• Molecular Formula: C₁₃H₉ClO
• Molecular Weight: 216.66
• EINECS: 200-589-5
• Mol File: 216443-25-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 363.5 °C at 760 mmHg
• Flash Point: 187.3 °C
• Appearance: /
• Density: 1.214g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3'-CHLORO-BIPHENYL-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-CHLORO-BIPHENYL-2-CARBALDEHYDE(216443-25-3)
• EPA Substance Registry System: 3'-CHLORO-BIPHENYL-2-CARBALDEHYDE(216443-25-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 216443-25-3(Hazardous Substances Data)

Usage

General Description

3'-Chloro-biphenyl-2-carbaldehyde is a chemical compound with the molecular formula C13H9ClO. It is a derivative of biphenyl, consisting of two benzene rings linked by a single carbon-carbon bond. The compound features a chloro group positioned at the third carbon atom of one of the benzene rings and an aldehyde functional group attached to the second carbon atom of the other benzene ring. It is commonly used as a building block in organic synthesis and pharmaceutical research. This chemical is known for its potential applications in the production of various organic compounds and materials due to its versatile reactivity and functional group compatibility. However, it is important to handle and use this compound with caution, as it may pose health and safety risks if not handled properly.

Upstream product

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• 82632-38-0 N-tert-butyl-1-(2-methoxyphenyl)methanimine 
• 36229-42-2 (3-chlorophenyl)magnesium bromide 
• 579-72-6 2-(dimethylamino)benzaldehyde 
• 108-37-2 1-bromo-3-chlorobenzene 
• 135-02-4 ortho-anisaldehyde 
• 93308-05-5 7-<3-Chlor-phenyl>-tropiliden 

Downstream Products

• 1292302-54-5 3-chloro-9-[(4-methylphenyl)sulfonylamino]fluorene 
• 1430810-73-3 1-(3'-chlorobiphenyl-2-ylmethyl)-4-(2-methoxyphenyl)piperazine 

Relevant articles and documents

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

Chromium-Catalyzed, Regioselective Cross-Coupling of C-O Bonds by Using Organic Bromides as Reactants

We report a chromium-catalyzed cross-coupling of C-O bonds with widely accessible organic bromides as reactants for the preparation of ortho -arylated or -alkylated aromatic aldehydes at room temperature. The use of metallic magnesium is essential for the reaction to occur, giving it an advantage over previous reactions involving Grignard reagents that have to be prepared separately from organic halides before the coupling.

Synthesis of dibenzopyranones and pyrazolobenzopyranones through copper(0)/Selectfluor system-catalyzed double C[sbnd]H activation/oxygen insertion of 2-arylbenzaldehydes and 5-arylpyrazole-4-carbaldehydes

A mild and efficient protocol for the synthesis of dibenzopyranones and pyrazolobenzopyranones was developed involving a copper(0)/Selectfluor system-catalyzed double C[sbnd]H activation/oxygen insertion of 2-arylbenzaldehydes and 5-arylpyrazole-4-carbaldehydes. Preliminary mechanistic studies suggest that both water and dioxygen act as the oxygen source in the formation of pyranone scaffolds.