216484-82-1Relevant articles and documents
Ergosteroids III. Syntheses and biological activity of seco-steroids related to dehydroepiandrosterone
Reich, Ieva L.,Lardy, Henry,Wei, Yong,Marwah, Padma,Kneer, Nancy,Powell, Douglas R.,Reich, Hans J.
, p. 542 - 553 (1998)
The unusual activity of some D-ring-seco estrogens led us to prepare several seco steroids related to dehydroepiandrosterone (DHEA) and to test for their ability to mimic thyroid hormone and 7-oxo-DHEA (1) as inducers of thermogenic enzymes in rats' livers. Only one, 3β-acetoxy-17a-oxa-androst- 5-ene-7,17-dione (17), was capable of inducing both mitochondrial glycerophosphate dehydrogenase and malic enzyme. The closely related 3β- hydroxy-17a-oxa-androsta-5,15-diene- 7,17-diones (both 14α and 14β, 14 and 15) induce the formation of malic enzyme but not of glycerophosphate dehydrogenase. The 3β-propionyl ester of the above 14α steroid was not active, presumably because it was not deacylated in vivo. The 16,17 dicarboxylic acid (9) produced by opening the D-ring also induced the formation of malic enzyme but not of glycerophosphate dehydrogenase. 3β- Acetoxyandrost-5-ene-7,16,17-trione, an intermediate in the synthesis of D- ring seco compounds enhanced the formation of both enzymes. Twelve other D- ring seco compounds were not active. Seco androstanes oxygenated at position 7 and with expanded A or B rings were not active.
