21658-95-7 Usage
Description
Diisopropyl Cyanomethylphosphonate, also known as DFP, is an organophosphorus compound with the chemical formula (C3H7O)2P(O)CH2CN. It is a colorless, oily liquid with a faint, fruity odor. DFP is a potent inhibitor of acetylcholinesterase, an enzyme that plays a crucial role in the nervous system. Due to its high reactivity and potential toxicity, it requires careful handling and storage.
Uses
Used in Pharmaceutical Industry:
Diisopropyl Cyanomethylphosphonate is used as a chemical reagent for the synthesis of elfamycin intermediates, which are important building blocks in the production of various antibiotics, such as erythromycin and oleandomycin. These antibiotics are widely used to treat bacterial infections in humans and animals.
Used in Chemical Research:
DFP is also utilized in chemical research for studying the mechanism of action of organophosphorus compounds on acetylcholinesterase inhibition. This research helps in understanding the toxic effects of nerve agents and the development of potential antidotes or therapeutic agents for nerve agent exposure.
Check Digit Verification of cas no
The CAS Registry Mumber 21658-95-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,6,5 and 8 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 21658-95:
(7*2)+(6*1)+(5*6)+(4*5)+(3*8)+(2*9)+(1*5)=117
117 % 10 = 7
So 21658-95-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H16NO3P/c1-7(2)11-13(10,6-5-9)12-8(3)4/h7-8H,6H2,1-4H3
21658-95-7Relevant articles and documents
Total Synthesis of Biselyngbyolide B
Sato, Eisuke,Tanabe, Yurika,Nakajima, Naoya,Ohkubo, Akifumi,Suenaga, Kiyotake
, p. 2047 - 2049 (2016)
The first total synthesis of biselyngbyolide B, an 18-membered macrolide, was achieved. The 18-membered ring structure was constructed by esterification using the Shiina reagent and an intramolecular Stille coupling reaction.
Biosynthesis of Naturally Products with a P-C Bond. Part 6. Preparation of Deuterium- and Carbon-13-Labelled L-Alanyl- and L-Alanyl-L-alanyl-(2-aminoethyl)phosphonic Acids and their Use in Biosynthetic Studies of Fosfomycin in Streptomyces fradiae
Hammerschmidt, Friedrich,Kaehlig, Hanspeter,Mueller, Norbert
, p. 365 - 369 (2007/10/02)
(2-Aminoethyl)phosphonic acid (AEP) is not taken up by Streptomyces fradiae in the biosynthesis of fosfomycin.Attachment of L-alanine or L-alanyl-L-alanine to the amino group of deuteriated AEP affords di- and tri-peptides 4 and 5 which are transported into the cell. AEP is synthesized from Na(13)CN and the tosyloxymethylphosphonate 7.It is transformed into dipeptide 4d, which acts as a carrier for AEP which is incorporated into fosfomycin with an enrichment of 2 percent.