216663-81-9 Usage
Description
(R)-1-(3'-bromo-6'-methoxyphenyl)-ethanol, also known as (R)-3-Bromo-6-methoxyphenyl ethanol, is an organic compound characterized by its molecular formula C9H11BrO2. As a chiral molecule, it possesses the (R) configuration, which denotes a specific three-dimensional arrangement of atoms. This unique structure endows it with distinct properties that are valuable in various applications.
Uses
Used in Pharmaceutical Industry:
(R)-1-(3'-bromo-6'-methoxyphenyl)-ethanol is used as an intermediate in the synthesis of pharmaceuticals and organic chemicals. Its specific chemical structure and reactivity make it a valuable component in the development of complex molecules and new drugs.
Used in Organic Chemistry:
In the field of organic chemistry, (R)-1-(3'-bromo-6'-methoxyphenyl)-ethanol is utilized as a key intermediate for the synthesis of various organic compounds. Its unique properties facilitate its involvement in organic reactions, contributing to the creation of a wide range of chemical products.
Used in Drug Development:
The potential applications of (R)-1-(3'-bromo-6'-methoxyphenyl)-ethanol extend to the development of new drugs. Its specific configuration and reactivity make it a promising candidate for the creation of novel pharmaceuticals, particularly in the context of complex molecular synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 216663-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,6,6,6 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 216663-81:
(8*2)+(7*1)+(6*6)+(5*6)+(4*6)+(3*3)+(2*8)+(1*1)=139
139 % 10 = 9
So 216663-81-9 is a valid CAS Registry Number.
216663-81-9Relevant articles and documents
Dinuclear zinc complex catalyzed asymmetric methylation and alkynylation of aromatic aldehydes
Liu, Shanshan,Li, Gao-Wei,Yang, Xiao-Chao,Zhang, De-Yang,Wang, Min-Can
, p. 7147 - 7156 (2017/09/07)
A general AzePhenol dinuclear zinc catalytic system has been successfully developed and introduced into the asymmetric addition of dimethylzinc and alkynylzinc to aromatic aldehydes. In this system, an azetidine derived chiral ligand has proven to be an effective enantioselective promoter. Under the optimal reaction conditions, a series of chiral 1-hydroxyethyl (up to 99% ee) and secondary propargylic alcohols (up to 96% ee) were generated with good yields and enantioselectivities. Additionally, this novel catalytic system showed good functional group compatibility. Remarkably, the substituent's electronic nature alone is not sufficient to allow for exclusive enantioselectivity, an additional substituent's location also had an effect. We proposed that the formation of a stable and structural rigid transition state by the chelation of ortho substituted benzaldehydes to the zinc atom was responsible for the observed higher enantioselectivity. The possible catalytic cycles of both transformations accounting for the stereoselectivity were described accordingly.
On the efficacy of propeller-shaped, C3-symmetric triarylphosphines in asymmetric catalysis
Powell, Mark T.,Porte, Alexander M.,Burgess, Kevin
, p. 2161 - 2162 (2007/10/03)
Ligand sets 1 and 2 were prepared and examined for evidence of C3-symmetric propeller-shaped conformations in solution, and for their ability to induce enantioselectivity in an allylation reaction.
