216690-19-6 Usage
Description
4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL is an organic compound that serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds. It is characterized by the presence of a fluorophenyl group attached to a piperidinemethanol moiety, which contributes to its unique chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL is used as a reagent for the preparation of pyrimidine derivatives, which are known to act as inhibitors of cytokines. These inhibitors play a crucial role in the treatment of immunological diseases by modulating the immune response and reducing inflammation.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL serves as a valuable building block for the development of novel therapeutic agents. Its unique structure allows for the design and synthesis of new compounds with potential applications in various therapeutic areas, including immunology, oncology, and neurology.
Used in Chemical Synthesis:
4-(4-FLUOROPHENYL)-3-PIPERIDINEMETHANOL is also utilized in various chemical synthesis processes, where its fluorophenyl and piperidinemethanol moieties can be further modified or functionalized to create a wide range of chemical products. These products can be used in different industries, such as agrochemicals, materials science, and specialty chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 216690-19-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,6,6,9 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 216690-19:
(8*2)+(7*1)+(6*6)+(5*6)+(4*9)+(3*0)+(2*1)+(1*9)=136
136 % 10 = 6
So 216690-19-6 is a valid CAS Registry Number.
InChI:InChI=1/C12H16FNO/c13-11-3-1-9(2-4-11)12-5-6-14-7-10(12)8-15/h1-4,10,12,14-15H,5-8H2
216690-19-6Relevant articles and documents
Novel process
-
, (2008/06/13)
Compounds of structure (1) are obtained by reduction of compounds of the structures Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are important intermediates for inter alia paroxetine.
Novel process
-
, (2008/06/13)
A process for the preparation of a 4-aryl-3-oxymethyl-piperidine of structure (1) in which R is hydrogen or an alkyl, arylalkyl, allyl, acyl, carbonyloxyalkyl, carbonyloxyaryl, or carbonyloxyalkylaryl group, and Y is a hydrogen atom or an optionally substituted alkyl, arylalkyl, or aryl group, from a carboxy derivative of structure (2) where A is oxygen or sulphar, X is one or more of hydrogen, or a readily reducible group, Z represents either a hydrogen atom or an OY′ group in which Y′ is independently selected from the same groups as Y, and the broken line circle indicates bonding, appropriate to a tetrahydropyridine, dihydropyridine, pyridine, or piperidine ring said process comprising (a) when Y is a hydrogen atom, reducing the compound of structure (2), or (b) when Y is other than a hydrogen atom (i) forming an ether from the alcohol product of step (a), (ii) etherifying the aldehyde compound of structure (2) in which Z is hydrogen, or (iii) reducing the ester compound of structure (2) in which Z is OY′.
Process for the preparation of 3-substituted 4-phenyl-piperidine derivatives
-
, (2008/06/13)
Described herein is the process for the preparation of 3-substituted 4-phenyl-piperidine derivatives of formula (I) in which X is selected from H and F, and R is selected from the group consisting of H, C1-C6 alkyl, C3-C6 alkenyl, and benzyl, comprising three steps starting from the monoamide of malonic acid and cinnamic aldehyde, or derivatives thereof.
