21681-03-8Relevant articles and documents
On the Diterpenoids of Andrographis paniculata: X-Ray Crystallographic Analysis of Andrographolide and Structure Determination of New Minor Diterpenoids
Fujita, Tetsuro,Fujitani, Ryujiro,Takeda, Yoshio,Takaishi, Yoshihisa,Yamada, Toshihide,et al
, p. 2117 - 2125 (2007/10/02)
The crystal structure of andrographolide (8) was determined and the absolute configuration at C-14, which was previously undecided, was established as R.Reexamination of the constituents of Andrographis paniculata NEES resulted in the isolation of three new diterpenoids of ent-labdane type, andrographanin, andropanoside, and 14-deoxy-12-methoxy-andrographolide, together with three known compounds, 14-deoxyandrographolide (4), neoandrographolide (5) and andrographolide (8).The structures of the new diterpenoids were determined to be 1, 2, and 3 on the basis of spectral and chemical evidence.Keywords - Andrographis paniculata; acanthaceae; andrographolide; X-ray analysis; andrograpanin; andropanoside, 14-deoxy-12-methoxy-andrographolide; ent-labdane diterpenoid; structure elucidation