216970-84-2

Basic information

• Product Name: 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one
• Synonyms: 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one
• CAS NO: 216970-84-2
• Molecular Weight: 440.4
• Mol File: 216970-84-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one(216970-84-2)
• EPA Substance Registry System: 3-trifluoromethanesulfonyl-5-(4-methoxyphenyl)-6-(4-pyridyl)-1-methyl-1H-pyridin-2-one(216970-84-2)

Safety Data

• Hazardous Substances Data: 216970-84-2(Hazardous Substances Data)

Upstream product

• 216970-80-8 2-benzyloxy-N-[2-(4-methoxy-phenyl)-1-pyridin-4-yl-vinyl]-N-methyl-acetamide 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 216970-82-0 3-(4-methoxyphenyl)-6-(4-pyridyl)-3-hydroxy-1-methyl-1H-pyridin-2-one 
• 216970-81-9 3-(benzyloxy)-5-(4-methoxyphenyl)-6-(pyridin-4-yl)-1-methyl-1H-pyridin-2-one 
• 216970-75-1 2-(4-methoxyphenyl)-3-oxo-3-(pyridin-4-yl)propionic acid methyl ester 
• 40061-24-3 2-(4-methoxyphenyl)-1-(4-pyridyl)ethan-1-one 
• 55-22-1 pyridine-4-carboxylic acid 
• 90322-87-5 1-isonicotinoyl-1H-imidazole 

Relevant articles and documents

SUBSTITUTED 1H-PYRIDINYL-2-ONES AS GABAA ALPHA 2/3 LIGANDS

Compounds according to Formula (I) or a salt thereof are selective ligands for GABA A receptors useful for treatment of disorders of the central nervous system:

A convenient synthesis of highly substituted 2-pyridones

A rapid and convenient synthesis of the 3-trifluoromethanesulfonyloxy- 2-pyridone 2, one of the first examples of this class of compound, was achieved by Vilsmeier formylation and cyclisation of the acyl enamine 6. The triflate 2 was found to undergo a ra