21711-85-3Relevant articles and documents
Employing Arynes for the Generation of Aryl Anion Equivalents and Subsequent Reaction with Aldehydes
Gaykar, Rahul N.,Bhunia, Anup,Biju, Akkattu T.
, p. 11333 - 11340 (2018/07/21)
Arynes are highly reactive intermediates, which are utilized for the electrophilic arylation of various X-H bonds (X = O, N, S etc.). Herein, a new synthetic strategy is demonstrated, where arynes are converted into aryl anion equivalents by treatment with phosphines and a base. The addition of phosphines to arynes form the phosphonium salts, which in the presence of a carbonate base generates the aryl anion equivalent. Subsequent addition of the aryl anions with aldehydes afforded the secondary alcohols.
Enantioselective Synthesis of Succinic Acids and γ-Lactones via Palladium Catalysed Allylic Substitution Reactions
Dawson, Graham J.,Williams, Jonathan M. J.,Coote, Steven J.
, p. 2535 - 2546 (2007/10/03)
The palladium catalyzed reaction between non-symmetrical allyl acetates and sodiodimethylmalonate proceeds in high yields and enantioselectivities (up to 99percent ee) using a diphenylphosphinoaryl oxazoline ligand.The so-formed substitution products are transformed into enantiomerically enriched succinic acids and also into enantiomerically enriched γ-lactones.
