21731-96-4

Basic information

• Product Name: 5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide
• Synonyms: 1H-1,2,4-triazole-1-carboximidothioic acid, 5-amino-N-methyl-; 5-amino-N-methyl-1H-1,2,4-triazole-1-carbimidothioic acid
• CAS NO: 21731-96-4
• Molecular Formula: C₄H₇N₅S
• Molecular Weight: 157.1969
• Mol File: 21731-96-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 348.7°C at 760 mmHg
• Flash Point: 164.7°C
• Density: 1.6g/cm³
• Vapor Pressure: 4.93E-05mmHg at 25°C
• Refractive Index: 1.769
• CAS DataBase Reference: 5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide(21731-96-4)
• EPA Substance Registry System: 5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide(21731-96-4)

Safety Data

• Hazardous Substances Data: 21731-96-4(Hazardous Substances Data)

Usage

General Description

5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide is a chemical compound with the molecular formula C4H7N5S. It is a derivative of 1,2,4-triazole and contains an amino group and a methyl group. 5-amino-N-methyl-1H-1,2,4-triazole-1-carbothioamide has potential applications in medicinal chemistry, particularly as a candidate for the development of antifungal or antimicrobial agents. It may also have uses in agricultural chemicals or as a research tool in biochemistry. The carbothioamide functional group in this compound gives it unique properties and potential for specific interactions with biological targets. Further research and development may uncover additional potential uses for this chemical.

Upstream product

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 556-61-6 methyl thioisocyanate 

Downstream Products

• 35101-92-9 NSC145180 

Relevant articles and documents

Antimicrobial and anti-biofilm activity of thiourea derivatives bearing 3-amino-1H-1,2,4-triazole scaffold

A set of 21 thiourea derivatives were prepared through reacting 3-amino-1H-1,2,4-triazole with the commercial aliphatic and aromatic isothiocyanates. The aliphatic isothiocyanate was used as a reagent leading to substitution on NH atom of 3-aminotriazole

Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia

In order to develop novel antiasthmatic agents based on a new mechanism of action, a series of 3-substituted 5-amino-1- [(methylamino)(thiocarbonyl)]-1H-1,2,4-triazole derivatives were synthesized and evaluated in a model in which eosinophilia was induced in the airway through intravenous (iv) injection of Sephadex particles on days 0, 2, and 5. After screening of several hundred derivatives, we finally identified the highly potent eosinophilia inhibitor 5-amino-3-(4-chlorophenyl)-1- [(methylamino)(thiocarbonyl)]-1H-triazole (23c, GCC-AP0341), which had ID50 values of 0.3 and 0.07 mg/kg when administered orally (os) and intraperitoneally (ip), respectively. This compound showed complete inhibition of the hypersensitivity induced by ascaris inhalation at an ip dose of 1 mg/kg as well as low toxicity, with an LD50 value of >2.0 g/kg in mice. Extensive study of its mechanism of action revealed that 23c inhibited eosinophil survival induced by interleukin-5 (IL-5), but had little or no effect on leukotriene D4 (LTD4) or platelet-activating factor (PAF)- induced responses. Taken together, these results suggest 23c as a novel candidate for the treatment of chronic asthma. Further studies are now underway.