21742-00-7 Usage
Description
2-(Trifluoromethyl)benzyl chloride, also known as α,α,α-trifluorotoluene, is an organic compound characterized by the presence of a trifluoromethyl group attached to a benzyl chloride moiety. It is a clear light yellow liquid with unique chemical properties that make it a versatile building block in the synthesis of various organic compounds.
Uses
Used in Pharmaceutical Industry:
2-(Trifluoromethyl)benzyl chloride is used as a key intermediate in the synthesis of phenyl-substituted carboxylic acid derivatives, which serve as potent inhibitors of Platelet Activator Inhibitor-1 (PAI-1). These inhibitors play a crucial role in the treatment of various thrombotic and cardiovascular diseases by regulating the balance between clot formation and dissolution in the blood.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(Trifluoromethyl)benzyl chloride is utilized as a valuable building block for the preparation of complex organic molecules. For instance, it reacts with 2-benzo[b]thienyllithium to yield 6-fluorobenzo[b]naphtho[2,3-d]thiophene, a compound with potential applications in various industries, including pharmaceuticals and materials science.
Chemical Properties:
2-(Trifluoromethyl)benzyl chloride is a clear light yellow liquid, which indicates its relatively low molecular weight and non-polar nature. This property, along with its reactivity, makes it an ideal candidate for use in various chemical reactions and synthesis processes.
Check Digit Verification of cas no
The CAS Registry Mumber 21742-00-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,4 and 2 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 21742-00:
(7*2)+(6*1)+(5*7)+(4*4)+(3*2)+(2*0)+(1*0)=77
77 % 10 = 7
So 21742-00-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H10F12O2/c19-15(20,21)13(31,16(22,23)24)11-5-1-9(2-6-11)10-3-7-12(8-4-10)14(32,17(25,26)27)18(28,29)30/h1-8,31-32H
21742-00-7Relevant articles and documents
Preparation method of 2-methyl-5-aminotrifluorotoluene
-
, (2017/06/24)
The invention provides a preparation method of 2-methyl-5-aminotrifluorotoluene. The method comprises the following steps: reducing 2-trifluoromethylbenzaldehyde, serving as a raw material, with sodium borohydride to obtain 2-trifluoromethyl benzyl alcohol; performing chlorination by sulfoxide chloride to obtain 2-trifluoromethyl benzyl chloride; nitrifying to obtain 2-chloromethyl-5-nitryltrifluorotoluene; lastly, performing hydrogenation reduction to obtain a target product, namely, 2-methyl-5-aminotrifluorotoluene. The method has the advantages of easiness in operation, high product yield, low cost and easiness in industrialization. The chemical formula of the 2-methyl-5-aminotrifluorotoluene is shown in the description.
Synthesis of 1-methyl-1-(substituted benzyl)hydrazines.
Butler,Alexander,McLean,Strand
, p. 1052 - 1054 (2007/10/05)
-
