21747-46-6 Usage
Description
(+)-LEDENE, also known as a carbotricyclic sesquiterpene, is a naturally occurring compound derived from several natural sources, including Australian Tea Tree oil (Melaleuca alternifolia). It can be prepared from (+)-aromadendrene via isomerization and is synthesized by viridiflorene synthase. This essential oil has garnered attention for its potential applications in various fields due to its antioxidant, antimicrobial, antibiofilm properties, and its potential in treating various cancers.
Uses
Used in Pharmaceutical Industry:
(+)-LEDENE is used as an antioxidant for its ability to combat oxidative stress and protect cells from damage. This property makes it a valuable candidate for the development of pharmaceutical products aimed at treating conditions related to oxidative stress.
Used in Antimicrobial Applications:
(+)-LEDENE is used as an antimicrobial agent due to its ability to inhibit the growth of microorganisms, making it a potential candidate for the development of new antibiotics and antifungal agents.
Used in Anti-Biofilm Applications:
(+)-LEDENE is used as an antibiofilm agent to disrupt and prevent the formation of biofilms, which are complex communities of microorganisms that adhere to surfaces and are often resistant to conventional treatments. This application can be particularly useful in the medical and industrial sectors, where biofilm-related infections and contamination are common issues.
Used in Cancer Treatment:
(+)-LEDENE is used as a potential cancer treatment agent, as it has been studied for its ability to target various types of cancer. Its multifaceted properties, including antioxidant, antimicrobial, and antibiofilm activities, make it a promising candidate for further research and development in the field of oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 21747-46-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,7,4 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 21747-46:
(7*2)+(6*1)+(5*7)+(4*4)+(3*7)+(2*4)+(1*6)=106
106 % 10 = 6
So 21747-46-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H24/c1-9-6-8-12-14(15(12,3)4)13-10(2)5-7-11(9)13/h10,12-14H,5-8H2,1-4H3
21747-46-6Relevant articles and documents
Biomimetic synthesis of (+)-ledene, (+)-viridiflorol, (-)-palustrol, (+)-spathulenol, and psiguadial A, C, and D via the platform terpene (+)-bicyclogermacrene
Tran, Duc N.,Cramer, Nicolai
, p. 10654 - 10660 (2014/11/07)
(+)-Bicyclogermacrene is a strained bicyclic and common sesquiterpene found in several essential oils. A short and good yielding synthesis of bicyclogermacrene proceeding in seven steps is reported. This terpene is used as key platform intermediate for a biomimetic access to several aromadendrene sesquiterpenoids, such as ledene, viridiflorol, palestrol, and spathulenol. Furthermore, bicyclogermacrene is shown to be the terpene component in the synthesis of the meroterpenoids psiguadial A, C, and D. Let nature be your guide! A concise synthesis of the terpene (+)-bicyclogermacrene enables its use as a platform for a fast access to a range of different terpenoids of the aromadendrene family and meroterpenoids of the psiguadial family (see scheme).
NEW TERPENOIDS OF THE ESSENTIAL OIL OF LEDUM PALUSTRE
Belousova, N. I.,Tkachev, A. V.,Shakirov, M. M.,Khan, V. A.
, p. 20 - 24 (2007/10/02)
The structures of two new natural compounds isolated from the essential oil of Ledum palustre L. have been established on the basis of their spectral characteristics as p-mentha-1,8(10)-diene 3,9-epoxide (lepaloks) and 3,10-epoxygermacr-4(14)-en-8-one (lepakson).The chemical structure of ledene as a sesquiterpene hydrocarbon has been determined by chemical correlation.
Katalytische Umwandlung von Sesquiterpenkohlenwasserstoffen an Alkalimetall/Aluminiumoxid-Kontakten
Rienaecker, Roland,Graefe, Juergen
, p. 348 - 349 (2007/10/02)
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