21762-78-7

Basic information

• Product Name: 6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE
• Synonyms: 6-Amino-4H-benzo[1,4]thiazin-3-one;6-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one
• CAS NO: 21762-78-7
• Molecular Formula: C₈H₈N₂OS
• Molecular Weight: 180.23
• Mol File: 21762-78-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 443.1 °C at 760 mmHg
• Flash Point: 221.8 °C
• Appearance: /
• Density: 1.38 g/cm³
• Vapor Pressure: 4.78E-08mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE(21762-78-7)
• EPA Substance Registry System: 6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE(21762-78-7)

Safety Data

• Hazardous Substances Data: 21762-78-7(Hazardous Substances Data)

Usage

Description

6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE is a heterocyclic organic compound with the molecular formula C8H6N2OS, featuring a benzothiazine backbone and an amino group at the 6th position. It serves as a key intermediate in the synthesis of various pharmaceuticals and is known for its potential antibacterial, antiviral properties, and use as a fluorescent probe for metal ions in analytical chemistry.

Uses

Used in Pharmaceutical Industry:
6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE is used as a key intermediate in the synthesis of various pharmaceuticals, particularly for the production of antitubercular drugs such as moxifloxacin and delamanid. Its unique structure and properties make it a valuable component in the development of new medications.
Used in Medicinal Chemistry:
6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE is utilized in medicinal chemistry for drug development due to its potential antibacterial and antiviral properties. Its structure is of interest for the design and synthesis of new therapeutic agents targeting various diseases and conditions.
Used in Analytical Chemistry:
In the field of analytical chemistry, 6-AMINO-2H-1,4-BENZOTHIAZIN-3(4H)-ONE is used as a fluorescent probe for metal ions. This application allows for the detection and analysis of metal ions in various samples, contributing to research and quality control in different industries.

InChI:InChI=1/C8H8N2OS/c9-5-1-2-7-6(3-5)10-8(11)4-12-7/h1-3H,4,9H2,(H,10,11)

Upstream product

• 32403-69-3 2-(2,4-dinitrophenylthio)acetic acid 
• 85196-28-7 (2,4-dinitro-phenylsulfanyl)-acetic acid ethyl ester 
• 21762-74-3 6-nitro-3,4-dihydro-3-oxo-2H(1,4)benzothiazine 
• 2365-48-2 Methyl thioglycolate 
• 97-00-7 1-chloro-2,4-dinitro-benzene 

Downstream Products

• 1072827-33-8 toluene-4-sulfonic acid (S)-2-oxo-3-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-oxazolidin-5-ylmethyl ester 
• 1619974-69-4 [4-(4-methoxybenzyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl]carbamic acid tert-butyl ester 
• 1619974-68-3 6-amino-4-(4-methoxybenzyl)-4H-benzo[1,4]thiazin-3-one 
• 1403818-34-7 methyl 3-(7-((3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-6-yl)amino)-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzoate 
• 264235-45-2 6-amino-4-methyl-4H-benzo[1,4]thiazin-3-one 
• 1072794-48-9 (3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-carbamic acid benzyl ester 
• 1072792-97-2 [(rac)-3-hydroxy-4-(3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-ylamino)-butyl]-carbamic acid benzyl ester 
• 888038-51-5 1-(3,4,5-trifluoro-phenyl)-piperidine-4-carboxylic acid (3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-6-yl)-amide 
• 19670-06-5 3-ethyl-6-oxo-2-methyl-6,7-dihydro-5H-thiazolo[4',5':4,5]benzo[1,2-b][1,4]thiazinium; toluene-4-sulfonate 
• 91376-04-4 6-<3-(3,4-dimethoxyphenyl)ethylamino-2-hydroxy>propoxy-3,4-dihydro-3-oxo-2H(1,4)benzothiazine 
• 74396-66-0 6-{N'-[2-Oxo-cyclohex-(Z)-ylidene]-hydrazino}-4H-benzo[1,4]thiazin-3-one 

Relevant articles and documents

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SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF

The present invention relates to compounds according to Formula I and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

HETEROCYCLIDENE-N-(ARYL)ACETAMIDE DERIVATIVE

The blow-described formula (I): [Ch. 1] a compound represented by formula (I) : (wherein k, m, n, and p each represent 0 to 2; j and q represents 0 or 1; R1 represents a halogen atom, a hydrocarbon group, a heterocyclic group, an alkoxy group,